Commonalities in social and non-social cognitive impairments in adults with autism spectrum disorder and schizophrenia.
Commonalities in social and non-social cognitive impairments in adults with autism spectrum disorder and schizophrenia.
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DOI：
10.1016/j.schres.2013.05.013
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发表时间：
2013-08
影响因子：
4.5
通讯作者：
Minshew NJ
中科院分区：
文献类型：
--
作者：
Eack SM;Bahorik AL;McKnight SA;Hogarty SS;Greenwald DP;Newhill CE;Phillips ML;Keshavan MS;Minshew NJ
自闭症谱系障碍（ASD）和精神分裂症都是以社会和非社会认知障碍为特征的疾病，但这两种疾病中认知缺陷的程度和领域的共性仍不清楚。本研究检测了47名门诊精神分裂症患者、43名言语型ASD成人患者和24名健康志愿者的神经认知和社会认知功能。一个全面的神经心理电池评估处理速度，注意力，记忆力和解决问题的领域管理沿着的情绪处理的社会认知电池。结果表明，与健康个体相比，自闭症（分别为d =-0.97和-1.71）和精神分裂症（分别为d =-0.65和-1.48）的参与者在情绪处理和神经认知方面存在较大且显著的损伤。ASD和精神分裂症患者在任何认知领域的评估中没有观察到显着差异，两种疾病中最大的障碍区域是相同的，包括处理速度缓慢和无法理解情绪。这些研究结果表明，自闭症和精神分裂症的言语成年人所经历的认知挑战具有高度的相似性，并且潜在需要跨诊断补救方法来增强这些条件下的认知。
Autism spectrum disorder (ASD) and schizophrenia are both conditions that are characterized by impairments in social and non-social cognition, yet commonalities in the magnitude and domains of cognitive deficits across these two conditions remains unclear. This study examined neurocognitive and social-cognitive functioning in 47 outpatients with schizophrenia, 43 verbal adults with ASD, and 24 healthy volunteers. A comprehensive neuropsychological battery assessing processing speed, attention, memory, and problem-solving domains was administered along with a social-cognitive battery of emotion processing. Results demonstrated large and significant impairments in emotion processing and neurocognition relative to healthy individuals in participants with autism (d = -.97 and -1.71, respectively) and schizophrenia (d = -.65 and -1.48, respectively). No significant differences were observed between those with ASD and schizophrenia on any cognitive domain assessed, and the areas of greatest impairment were identical across both disorders and included slowness in speed of processing and an inability to understand emotions. These findings indicate a high degree of similarity in the cognitive challenges experienced by verbal adults with autism and schizophrenia, and the potential need for trans-diagnostic remediation approaches to enhance cognition in these conditions.
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影响因子：
--
作者：
Hogarty, GE;Flesher, S;Zoretich, R
通讯作者：
Zoretich, R
影响因子：
2.6
作者：
Goldstein, G;Minshew, NJ;Seaton, BE
通讯作者：
Seaton, BE
影响因子：
3.9
作者：
Lord, C;Risi, S;Rutter, M
通讯作者：
Rutter, M
影响因子：
4.5
作者：
Pilowsky, T;Yirmiya, N;Mozes, T
通讯作者：
Mozes, T
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y