Synaptic molecular imaging in spared and deprived columns of mouse barrel cortex with array tomography.
Synaptic molecular imaging in spared and deprived columns of mouse barrel cortex with array tomography.
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DOI：
10.1038/sdata.2014.46
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发表时间：
2014
期刊：
影响因子：
9.8
通讯作者：
Smith, Stephen J.
中科院分区：
文献类型：
--
作者：
Weiler, Nicholas C.;ColIman, Forrest;Vogelstein, Joshua T.;Burns, Randal;Smith, Stephen J.
A major question in neuroscience is how diverse subsets of synaptic connections in neural circuits are affected by experience dependent plasticity to form the basis for behavioral learning and memory. Differences in protein expression patterns at individual synapses could constitute a key to understanding both synaptic diversity and the effects of plasticity at different synapse populations. Our approach to this question leverages the immunohistochemical multiplexing capability of array tomography (ATomo) and the columnar organization of mouse barrel cortex to create a dataset comprising high resolution volumetric images of spared and deprived cortical whisker barrels stained for over a dozen synaptic molecules each. These dataset has been made available through the Open Connectome Project for interactive online viewing, and may also be downloaded for offline analysis using web, Matlab, and other interfaces.
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Anggono V;Huganir RL
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Huganir RL
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Boulland, JL;Qureshi, T;Chaudhry, FA
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Chaudhry, FA
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Feldman DE
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Feldman DE
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Smith, Stephen
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