Effects of cortisol on memory in women with borderline personality disorder: role of co-morbid post-traumatic stress disorder and major depression
Effects of cortisol on memory in women with borderline personality disorder: role of co-morbid post-traumatic stress disorder and major depression
复制标题
皮质醇对边缘性人格障碍女性记忆的影响：共病创伤后应激障碍和重度抑郁症的作用
DOI：
--
复制
发表时间：
2012
影响因子：
6.9
通讯作者：
Oliver T. Wolf
中科院分区：
文献类型：
--
作者：
K. Wingenfeld;Martin Driessen;Kirsten Terfehr;Nicole Schlosser;S. Fernando;Christian Otte;Thomas Beblo;Carsten Spitzer;Bernd Löwe;Oliver T. Wolf
背景压力和皮质醇管理是已知的损害影响健康人的记忆检索。据报道，这些影响在重度抑郁症（MDD）和创伤后应激障碍（PTSD）患者中会发生改变，但尚未在边缘型人格障碍（BPD）中进行研究。方法采用安慰剂对照的交叉研究方法，对71例BPD患者和40例健康对照者在进行陈述性记忆提取任务（词表学习）和自传体记忆测验（AMT）前分别口服安慰剂或氢化可的松10 mg。还进行了工作记忆测试。结果总体而言，皮质醇对记忆的相反影响，观察时，比较患者和对照组。在对照组中，皮质醇对记忆提取有损害作用，而在BPD患者中，皮质醇对单词的记忆提取、自传体记忆和工作记忆有增强作用。这些影响是最明显的自传体记忆提取的特异性。单独患有BPD的患者和患有共病PTSD的患者表现出这种效果。我们还发现，共病MDD影响皮质醇的影响：在这个亚组（BPD + MDD）的皮质醇对记忆的影响是不存在的。结论急性皮质醇升高对BPD患者大脑皮层介导的记忆过程有有益的影响。在合并MDD的患者中没有这些影响表明这些患者在对糖皮质激素（GC）的敏感性方面不同于其他BPD患者。
Background Stress and cortisol administration are known to have impairing effects on memory retrieval in healthy humans. These effects are reported to be altered in patients with major depressive disorder (MDD) and post-traumatic stress disorder (PTSD) but they have not yet been investigated in borderline personality disorder (BPD). Method In a placebo-controlled cross-over study, 71 women with BPD and 40 healthy controls received either placebo or 10 mg of hydrocortisone orally before undertaking a declarative memory retrieval task (word list learning) and an autobiographical memory test (AMT). A working memory test was also applied. Results Overall, opposing effects of cortisol on memory were observed when comparing patients with controls. In controls, cortisol had impairing effects on memory retrieval whereas in BPD patients cortisol had enhancing effects on memory retrieval of words, autobiographical memory and working memory. These effects were most pronounced for specificity of autobiographical memory retrieval. Patients with BPD alone and those with co-morbid PTSD showed this effect. We also found that co-morbid MDD influenced the cortisol effects: in this subgroup (BPD + MDD) the effects of cortisol on memory were absent. Conclusions The present results demonstrate beneficial effects of acute cortisol elevations on hippocampal-mediated memory processes in BPD. The absence of these effects in patients with co-morbid MDD suggests that these patients differ from other BPD patients in terms of their sensitivity to glucocorticoids (GCs).
登录
查看更多内容
影响因子：
--
作者：
E. Ronald;D. Kloet
通讯作者：
E. Ronald;D. Kloet
影响因子：
4.8
作者：
Bernstein, DP;Stein, JA;Zule, W
通讯作者：
Zule, W
影响因子：
1.7
作者：
Yehuda, R
通讯作者：
Yehuda, R
边缘性人格障碍的神经影像学。
影响因子：
4.8
作者：
Schmahl,Christian;Bremner,JDouglas
通讯作者：
Bremner,JDouglas
影响因子：
120.7
作者：
Heim, C;Newport, DJ;Nemeroff, CB
通讯作者：
Nemeroff, CB