The molecular mechanisms underlying lens fiber elongation.

The molecular mechanisms underlying lens fiber elongation.
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DOI:
10.1016/j.exer.2016.03.016
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发表时间:
2017-03
影响因子:
3.4
通讯作者:
Duncan, Melinda K.
Duncan, Melinda K.
中科院分区:
医学3区
文献类型:
--
作者:
Audette, Dylan S.;Scheiblin, David A.;Duncan, Melinda K.

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晶状体纤维细胞是高度细长的细胞,具有复杂的膜形态,对晶状体的透明度至关重要。对晶状体纤维细胞伸长的分子机制的研究在20世纪60年代首次报道,然而,近50年后,我们对这一过程的理解仍然很差。这篇综述总结了目前关于晶状体纤维细胞伸长调节的假设,以及现有的实验证据,以及这些信息如何与其他细胞类型,特别是神经元中已知的细胞形状/伸长调节有关。
Lens fiber cells are highly elongated cells with complex membrane morphologies that are critical for the transparency of the ocular lens. Investigations into the molecular mechanisms underlying lens fiber cell elongation were first reported in the 1960s, however, our understanding of the process is still poor nearly 50 years later. This review summarizes what is currently hypothesized about the regulation of lens fiber cell elongation along with the available experimental evidence, and how this information relates to what is known about the regulation of cell shape/elongation in other cell types, particularly neurons.
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