An Open Question: Is Non-Ionizing Radiation a Tool for Controlling Apoptosis-Induced Proliferation?
An Open Question: Is Non-Ionizing Radiation a Tool for Controlling Apoptosis-Induced Proliferation?
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DOI：
10.3390/ijms222011159
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发表时间：
2021-10-16
影响因子：
5.6
通讯作者：
Beane WS
中科院分区：
文献类型：
--
作者：
Hack SJ;Kinsey LJ;Beane WS
非电离辐射通常用于临床环境中，尽管其已知能够引发氧化应激和细胞凋亡，这可能导致损伤和细胞死亡。虽然诱导细胞死亡通常被认为是有害的，但在正确的情况下，凋亡也可能是有益的。例如，细胞死亡可以作为新组织生长的信号，例如在细胞凋亡诱导的增殖中。最近的数据表明，暴露于非电离辐射（如弱静磁场、弱射频磁场和弱电磁场）能够调节细胞培养物和活生物体（例如组织再生期间）的增殖。这通过活性氧（ROS）水平的体内变化而发生，活性氧是细胞凋亡的典型激活剂。这篇综述将描述的文献，突出了诱人的可能性，非电离辐射可用于操纵骨化诱导的增殖，以促进生长（再生医学）或抑制它（癌症治疗）。然而，由于不受控制的生长可能导致肿瘤发生，因此需要对这个令人兴奋和发展中的领域进行更多的研究，以实现其承诺。
Non-ionizing radiation is commonly used in the clinical setting, despite its known ability to trigger oxidative stress and apoptosis, which can lead to damage and cell death. Although induction of cell death is typically considered harmful, apoptosis can also be beneficial in the right context. For example, cell death can serve as the signal for new tissue growth, such as in apoptosis-induced proliferation. Recent data has shown that exposure to non-ionizing radiation (such as weak static magnetic fields, weak radiofrequency magnetic fields, and weak electromagnetic fields) is able to modulate proliferation, both in cell culture and in living organisms (for example during tissue regeneration). This occurs via in vivo changes in the levels of reactive oxygen species (ROS), which are canonical activators of apoptosis. This review will describe the literature that highlights the tantalizing possibility that non-ionizing radiation could be used to manipulate apoptosis-induced proliferation to either promote growth (for regenerative medicine) or inhibit it (for cancer therapies). However, as uncontrolled growth can lead to tumorigenesis, much more research into this exciting and developing area is needed in order to realize its promise.
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