Association between urinary salt excretion and albuminuria in Japanese patients with chronic kidney disease: the Fukuoka kidney disease registry study
Association between urinary salt excretion and albuminuria in Japanese patients with chronic kidney disease: the Fukuoka kidney disease registry study
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日本慢性肾病患者尿盐排泄与蛋白尿之间的关联：福冈肾病登记研究
DOI：
10.1007/s10157-020-01950-4
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发表时间：
2020
影响因子：
2.3
通讯作者：
Kitazono Takanari
中科院分区：
文献类型：
--
作者：
Fukui Akiko;Nakayama Masaru;Tanaka Shigeru;Matsukuma Yuta;Yoshitomi Ryota;Nakano Toshiaki;Tsuruya Kazuhiko;Kitazono Takanari
背景几项基于人群的大型研究表明，尿盐排泄 (USALT) 与蛋白尿有关。然而，这种关系尚未在慢性肾病（CKD）患者的大型队列研究中得到评估。因此，本研究旨在阐明 USALT 是否与一大群 CKD 患者中的蛋白尿独立相关。方法这项横断面研究在 4075 名未接受透析的 CKD 患者中进行。 USALT（克/天）是根据现场尿液估算的。根据估计的 USALT 将患者分为四分位数 (Q1-Q4)。使用多变量回归模型来确定 USALT 是否与尿白蛋白肌酐比 (UACR) 或大量白蛋白尿的存在独立相关。结果在多变量线性回归分析中，USALT 每天 1 克的增量与 UACR 对数显着相关 [系数 0.098，95% 置信区间 (CI) 0.075–0.121]。此外，与第一个 USALT 四分位数相比，第三和第四四分位数与 log UACR 显着相关（Q3：系数 0.305，95% CI 0.154–0.456；Q4：系数 0.601，95% CI 0.447–0.756）。此外，多变量逻辑回归分析显示 USALT（1 g/天增量）与大量白蛋白尿的存在显着相关 [比值比 (OR) 1.11，95% CI 1.07–1.14]；与第一个四分位数相比，第三个和第四个 USALT 四分位数表现出大量白蛋白尿的风险显着更高（Q3：OR 1.33，95% CI 1.09–1.62；Q4：OR 1.89，95% CI 1.54–2.32）。 结论 USALT 与 UACR 和大量白蛋白尿的显着相关性表明较高的 USALT 可能会导致白蛋白尿增加，从而促进肾脏疾病的进展。
BackgroundSeveral large population-based studies have demonstrated that urinary salt excretion (USALT) is associated with albuminuria. However, this relationship has not been assessed in a large cohort study of patients with chronic kidney disease (CKD). Thus, the present study aimed to elucidate whether USALT was independently associated with albuminuria in a large cohort of patients with CKD.MethodsThis cross-sectional study was conducted in 4075 patients with CKD not on dialysis. USALT (g/day) was estimated from spot urine. Patients were divided into quartiles (Q1–Q4) according to estimated USALT. Multivariable regression models were used to determine whether USALT was independently related to urinary albumin-to-creatinine ratio (UACR) or the presence of macroalbuminuria.ResultsIn multivariable linear regression analyses, 1-g/day increment in USALT was significantly associated with log UACR [coefficient 0.098, 95% confidence interval (CI) 0.075–0.121]. In addition, compared with the first USALT quartile, the third and fourth quartiles exhibited significant associations with log UACR (Q3: coefficient 0.305, 95% CI 0.154–0.456; Q4: coefficient 0.601, 95% CI 0.447–0.756). Furthermore, multivariable logistic regression analyses showed that USALT (1-g/day increment) was significantly associated with the presence of macroalbuminuria [odds ratio (OR) 1.11, 95% CI 1.07–1.14]; the third and fourth USALT quartiles exhibited significantly greater risks of macroalbuminuria, compared with the first quartile (Q3: OR 1.33, 95% CI 1.09–1.62; Q4: OR 1.89, 95% CI 1.54–2.32).ConclusionsThis significant association of USALT with UACR and macroalbuminuria suggests that higher USALT may cause increased albuminuria, thereby contributing to kidney disease progression.
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DOI：
10.1097/01.asn.0000092145.90389.65
发表时间：
2003-11-01
影响因子：
13.6
作者：
Kitiyakara, C;Chabrashvili, T;Wilcox, CS
通讯作者：
Wilcox, CS
影响因子：
2.7
作者：
Tanaka, T;Okamura, T;Hashimoto, T
通讯作者：
Hashimoto, T
影响因子：
3.2
作者：
Hu, Jiachang;Wang, Yimei;Ding, Xiaoqiang
通讯作者：
Ding, Xiaoqiang
影响因子：
8.9
作者：
Aaron KJ;Sanders PW
通讯作者：
Sanders PW
DOI：
10.1152/ajprenal.00388.2002
发表时间：
2003-10-01
影响因子：
4.2
作者：
Dobrian, AD;Schriver, SD;Prewitt, RL
通讯作者：
Prewitt, RL