Dystrophic dendrites in prefrontal cortical pyramidal cells of dopamine D1 and D2 but not D4 receptor knockout mice.
Dystrophic dendrites in prefrontal cortical pyramidal cells of dopamine D1 and D2 but not D4 receptor knockout mice.
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DOI：
10.1016/j.brainres.2009.09.008
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发表时间：
2009-12-01
期刊：
影响因子：
2.9
通讯作者：
Deutch, Ariel Y.
中科院分区：
文献类型：
--
作者：
Wang, Hui-Dong;Stanwood, Gregg D.;Grandy, David K.;Deutch, Ariel Y.
关键词：
最近的数据表明，皮质多巴胺去神经导致锥体细胞树突的营养不良性变化，包括树突棘密度和长度的减少。然而，目前尚不清楚是否通过特定的多巴胺受体信号的损失，这些树突状细胞的变化。我们检查了D1、D2和D4多巴胺受体缺失突变小鼠及其野生型同窝小鼠前额叶皮质中第V层锥体细胞的树枝状结构。在D1基因敲除小鼠中观察到基底树突长度和棘密度降低。类似地，与野生型同窝小鼠相比，D2基因敲除小鼠的基底树突棘密度降低。在D4敲除小鼠中未观察到任何树突参数的变化。这些观察结果表明，在前额叶皮质锥体细胞树突中观察到的营养不良性变化是由于通过D1和可能的D2受体的信号转导的损失。目前的数据还表明，在解释多巴胺受体敲除小鼠PFC的行为，生理和生化研究时应谨慎。
Recent data indicate that cortical dopamine denervation results in dystrophic changes in the dendrites of pyramidal cells, including decreases in dendritic spine density and length. However, it is not known if the loss of signaling through specific dopamine receptors subserves these dendritic changes. We examined the dendritic structure of layer V pyramidal cells in the prefrontal cortex of D1, D2, and D4 dopamine receptor null mutant mice and their wild-type littermates. Decreased basal dendritic length and spine density were observed in the D1 knockout mice. Similarly, a decrease in basal dendritic spine density was uncovered in the D2 knockout mice relative to wild-type littermates. No changes in any dendritic parameter were observed in the D4 knockout mice. These observations suggest that the dystrophic changes observed in prefrontal cortical pyramidal cell dendrites are due to loss of signaling through D1 and possibly D2 receptors. The current data also suggest that caution should be exercised in the interpretation of behavioral, physiological and biochemical studies of the PFC in dopamine receptor knockout mice.
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影响因子：
3.3
作者：
Desteno, D. A.;Schmauss, C.
通讯作者：
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影响因子：
4.5
作者：
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DOI：
10.1073/pnas.0308280101
发表时间：
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影响因子：
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通讯作者：
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影响因子：
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作者：
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作者：
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