Targeting and Therapeutic Monitoring of H3K27M-Mutant Glioma.
Targeting and Therapeutic Monitoring of H3K27M-Mutant Glioma.
复制标题
DOI：
10.1007/s11912-020-0877-0
复制
发表时间：
2020-02-06
影响因子：
4.7
通讯作者：
Koschmann C
中科院分区：
文献类型：
--
作者：
Wierzbicki K;Ravi K;Franson A;Bruzek A;Cantor E;Harris M;Homan MJ;Marini BL;Kawakibi AR;Ravindran R;Teodoro R;Yadav VN;Koschmann C
H3K27M 是弥漫性中线胶质瘤中常见的组蛋白突变，与不良预后相关，以至于 2016 年 CNS WHO 分类系统创建了一个特定类别“弥漫性中线胶质瘤，H3K27M 突变”。在这里，我们概述了针对 H3K27M 的最新临床前数据和当前正在进行的临床试验，并探索通过连续液体活检进行诊断和治疗监测。多种表观遗传化合物已在临床前模型中证明了功效和靶向作用。咪啶酮 ONC201 和 IDO1 抑制剂吲哚莫德已证明对 H3K27M 突变神经胶质瘤具有早期临床活性。脑脊液液体活检已显示出临床用于 H3K27M 突变肿瘤诊断和监测治疗反应的前景。虽然 H3K27M 已经引发了一个广泛的临床前治疗平台，但仍需要取得很大进展才能改善弥漫性中线神经胶质瘤患者的预后。我们介绍当前的治疗和监测技术以及识别和靶向 H3K27M 突变神经胶质瘤的新方法。
H3K27M is a frequent histone mutation within diffuse midline gliomas and is associated with a dismal prognosis, so much so that the 2016 CNS WHO classification system created a specific category of “Diffuse Midline Glioma, H3K27M-mutant”. Here we outline the latest pre-clinical data and ongoing current clinical trials that target H3K27M, as well as explore diagnosis and treatment monitoring by serial liquid biopsy. Multiple epigenetic compounds have demonstrated efficacy and on-target effects in pre-clinical models. The imipridone ONC201 and the IDO1 inhibitor indoximod have demonstrated early clinical activity against H3K27M-mutant gliomas. Liquid biopsy of cerebrospinal fluid has shown promise for clinical use in H3K27M-mutant tumors for diagnosis and monitoring treatment response. While H3K27M has elicited a widespread platform of pre-clinical therapies with promise, much progress still needs to be made to improve outcomes for diffuse midline glioma patients. We present current treatment and monitoring techniques as well as novel approaches in identifying and targeting H3K27M-mutant gliomas.
登录
查看更多内容
影响因子：
3.7
作者：
Hennika T;Hu G;Olaciregui NG;Barton KL;Ehteda A;Chitranjan A;Chang C;Gifford AJ;Tsoli M;Ziegler DS;Carcaboso AM;Becher OJ
通讯作者：
Becher OJ
表观遗传靶向治疗，用于弥漫性内在蓬托胶质瘤。
影响因子：
1.9
作者：
Hashizume R
通讯作者：
Hashizume R
影响因子：
7.9
作者：
Koschmann C;Farooqui Z;Kasaian K;Cao X;Zamler D;Stallard S;Venneti S;Hervey-Jumper S;Garton H;Muraszko K;Franchi L;Robertson PL;Leonard M;Opipari V;Castro MG;Lowenstein PR;Chinnaiyan A;Mody R
通讯作者：
Mody R
影响因子：
7.3
作者：
Kline CL;Van den Heuvel AP;Allen JE;Prabhu VV;Dicker DT;El-Deiry WS
通讯作者：
El-Deiry WS
影响因子：
82.9
作者：
通讯作者：
--