Epigenetic Targeted Therapy for Diffuse Intrinsic Pontine Glioma.
Epigenetic Targeted Therapy for Diffuse Intrinsic Pontine Glioma.
复制标题
表观遗传靶向治疗，用于弥漫性内在蓬托胶质瘤。
DOI：
10.2176/nmc.ra.2017-0018
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发表时间：
2017-07-15
影响因子：
1.9
通讯作者：
Hashizume R
中科院分区：
文献类型：
--
作者：
Hashizume R
弥漫性桥脑胶质瘤(DIPG)是一种少见的致命性脑癌，以5-7岁儿童发病率最高。与大多数类型的人类癌症相比，DIPG患者的治疗结果没有显著改善。由于DIPG发生在脑干，这是大脑的一个重要区域，没有外科手术可以为患者提供缓解，化疗和放射治疗充其量只能提供姑息缓解。到目前为止，与单纯姑息性放射治疗相比，超过250项评估放射治疗与传统细胞毒性化疗以及较新的生物制剂的临床试验未能改善令人沮丧的结果。最近发现的影响DIPG染色质调节的体细胞致癌基因突变极大地提高了我们对DIPG疾病发病机制的理解，这些发现刺激了针对表观遗传调节因子的疾病治疗的新的治疗方法的发展。本文将讨论组蛋白修饰在染色质机制中的作用以及治疗DIPG的表观遗传学策略。
Diffuse intrinsic pontine glioma (DIPG) is a rare but uniformly fatal cancer of the brain, with peak incidence in children of 5–7 years of age. In contrast to most types of human cancer, there has been no significant improvement in treatment outcomes for patients with DIPG. Since DIPG occurs in the brainstem, a vital region of the brain, there are no surgical options for providing relief to patients, and chemotherapy as well as radiation therapy provide palliative relief at best. To date, more than 250 clinical trials evaluating radiotherapy along with conventional cytotoxic chemotherapy, as well as newer biologic agents, have failed to improve the dismal outcome when compared with palliative radiation alone. The recent discovery of somatic oncogenic histone gene mutations affecting chromatin regulation in DIPG has dramatically improved our understanding of the disease pathogenesis in DIPG, and these findings have stimulated the development of novel therapeutic approaches targeting epigenetic regulators for disease treatment. This review will discuss about the role of histone modification in chromatin machinery and epigenetic therapeutic strategies for the treatment of DIPG.
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DOI：
10.1158/1078-0432.ccr-12-3066
发表时间：
2013-04-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Cheng Z;Gong Y;Ma Y;Lu K;Lu X;Pierce LA;Thompson RC;Muller S;Knapp S;Wang J
通讯作者：
Wang J
选择性抑制BET溴结构域。
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
64.8
作者：
Agger, Karl;Cloos, Paul A. C.;Helin, Kristian
通讯作者：
Helin, Kristian
影响因子：
64.5
作者：
Czermin, B;Melfi, R;Pirrotta, V
通讯作者：
Pirrotta, V
影响因子：
64.5
作者：
Delmore JE;Issa GC;Lemieux ME;Rahl PB;Shi J;Jacobs HM;Kastritis E;Gilpatrick T;Paranal RM;Qi J;Chesi M;Schinzel AC;McKeown MR;Heffernan TP;Vakoc CR;Bergsagel PL;Ghobrial IM;Richardson PG;Young RA;Hahn WC;Anderson KC;Kung AL;Bradner JE;Mitsiades CS
通讯作者：
Mitsiades CS