Structural alteration of the erythrocyte membrane during malarial parasite invasion and intraerythrocytic development.
Structural alteration of the erythrocyte membrane during malarial parasite invasion and intraerythrocytic development.
复制标题
疟疾寄生虫入侵和红细胞内发育过程中红细胞膜的结构改变。
DOI：
10.1002/9780470715444.ch4
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Miller,LH
中科院分区：
文献类型：
--
作者：
Aikawa,M;Miller,LH
疟疾裂殖子进入红细胞会导致红细胞膜的结构改变。首先，裂殖子进入红细胞需要在红细胞膜和裂殖子顶端之间形成连接。其次，平行于裂殖子长轴的连接处的迁移使裂殖子进入红细胞膜内陷。冷冻断裂研究表明，连接处由红细胞膜 P 面上的一条窄带菱形排列的膜内颗粒 (IMP) 和 E 面上匹配的菱形排列的凹坑组成。红细胞膜P面上的IMP在该交界处消失，导致源自红细胞膜的寄生液泡膜P面上不存在IMP。红细胞膜通过裂殖子后端的连接处以虹膜隔膜的形式融合而被密封。完成进入红细胞后，裂殖子被寄生液泡膜包围，该膜的分子组织与原始红细胞膜不同。此外，两种类型的红细胞膜修饰是由红细胞内寄生虫诱导的。它们包括沿着红细胞膜的称为旋钮的电子致密突起和小凹囊泡复合物。疟疾裂殖子侵入红细胞是疟疾寄生虫红细胞阶段发育的第一步。目前积累的信息表明，裂殖子通过一定的事件顺序进入红细胞：（1）裂殖子最初识别并附着在红细胞膜上；（2）裂殖子顶端与红细胞之间形成连接；（3）形成与红细胞连续的液泡膜
Erythrocyte entry by malarial merozoites causes structural alteration of the erythrocyte membrane. First, entry into erythrocytes by merozoites requires the formation of a junction between the erythrocyte membrane and the apical end of the merozoite. Secondly, migration of the junction parallel to the long axis of the merozoite brings the merozoite into an invagination of the erythrocyte membrane. Freeze-fracture studies show that the junction consists of a narrow band of rhomboidally arrayed intramembrane particles (IMP) on the P face of the erythrocyte membrane and matching rhomboidally arrayed pits on the E face. IMP on the P face of the erythrocyte membrane disappear beyond this junction, resulting in the absence of IMP from the P face of the parasitophorous vacuole membrane which originated from the erythrocyte membrane. The erythrocyte membrane is sealed off by fusion of the junction at the posterior end of the merozoite in the fashion of an iris diaphragm. After completing its entry into the erythrocyte the merozoite is surrounded by a parasitophorous vacuole membrane which is different in its molecular organization from the original erythrocyte membrane. In addition, two types of erythrocyte membrane modification are induced by intraerythrocytic parasites. They include electron-dense protrusions called knobs and caveola-vesicle complexes along the erythrocyte membrane.Invasion of erythrocytes by malarial merozoites is the initial step in the development of the erythrocytic stages of malarial parasites. The information that has now accumulated demonstrates that the merozoites enter the erythrocytes by a definite sequence of events:(1) initial recognition of and attachment of the merozoite to the erythrocyte membrane;(2) formation of a junction between the apical end of the merozoite and the erythrocyte;(3) creation of a vacuole membrane which is continuous with the erythrocyte
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DOI：
--
发表时间：
1981
期刊：
Growth
影响因子：
--
作者：
Webber,RJ;Sokoloff,L
通讯作者：
Sokoloff,L
人类精浆和精子中的微量元素。
DOI：
10.1016/0009-8981(83)90019-0
发表时间：
1983
期刊：
Clinica chimica acta; international journal of clinical chemistry
影响因子：
--
作者：
P. Pleban;D. Mei
通讯作者：
D. Mei
影响因子：
4.8
作者：
CORVOL, MT;SOKOLOFF, L;MALEMUD, CJ
通讯作者：
MALEMUD, CJ
单层培养中关节软骨细胞掺入硫酸盐。
影响因子：
--
作者：
L. Sokoloff;C. Malemud;W. T. Green
通讯作者：
W. T. Green
兔耳软骨细胞原代培养物在补充脂质的确定成分培养基中的克隆生长。
影响因子：
3.7
作者：
S. Jennings;R. Ham
通讯作者：
R. Ham