Screening for genes coding for putative antitumor compounds, antimicrobial and enzymatic activities from haloalkalitolerant and haloalkaliphilic bacteria strains of Algerian Sahara Soils.
Screening for genes coding for putative antitumor compounds, antimicrobial and enzymatic activities from haloalkalitolerant and haloalkaliphilic bacteria strains of Algerian Sahara Soils.
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DOI：
10.1155/2014/317524
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发表时间：
2014
影响因子：
--
通讯作者：
Hacène H
中科院分区：
文献类型：
--
作者：
Selama O;Amos GC;Djenane Z;Borsetto C;Laidi RF;Porter D;Nateche F;Wellington EM;Hacène H
极端环境通常可能含有不寻常的细菌群，其生理机能与正常环境不同。为了满足对新的生物活性药物化合物和酶的需求，我们在这里报道了从极端环境中分离出的新型细菌。从阿尔及利亚撒哈拉沙漠土壤中分离出13种耐盐和嗜盐细菌。使用基于PCR的方法筛选这些分离物是否存在编码推定抗肿瘤化合物的基因。酶、抗菌和抗真菌活性通过培养依赖法测定。这些分离物中有几个是典型的沙漠和碱性盐碱地，但是，此外，我们首次报道了诺卡菌属中一个潜在的新成员的存在，该成员对酿酒酵母具有特殊的活性。除了它们的卤碱特性外，已知的抗肿瘤化合物编码基因的存在，加上对多种指示菌株的抗菌活性及其酶促潜力，使它们适合生物技术应用。
Extreme environments may often contain unusual bacterial groups whose physiology is distinct from those of normal environments. To satisfy the need for new bioactive pharmaceuticals compounds and enzymes, we report here the isolation of novel bacteria from an extreme environment. Thirteen selected haloalkalitolerant and haloalkaliphilic bacteria were isolated from Algerian Sahara Desert soils. These isolates were screened for the presence of genes coding for putative antitumor compounds using PCR based methods. Enzymatic, antibacterial, and antifungal activities were determined by using cultural dependant methods. Several of these isolates are typical of desert and alkaline saline soils, but, in addition, we report for the first time the presence of a potential new member of the genus Nocardia with particular activity against the yeast Saccharomyces cerevisiae. In addition to their haloalkali character, the presence of genes coding for putative antitumor compounds, combined with the antimicrobial activity against a broad range of indicator strains and their enzymatic potential, makes them suitable for biotechnology applications.
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影响因子：
2.7
作者：
Hacene, H;Rafa, F;Ollivier, B
通讯作者：
Ollivier, B
DOI：
10.1099/ijs.0.028985-0
发表时间：
2012-07-01
影响因子：
2.8
作者：
Addou, Ammara Nariman;Schumann, Peter;Fardeau, Marie-Laure
通讯作者：
Fardeau, Marie-Laure
DOI：
10.1099/ijs.0.63866-0
发表时间：
2006-03-01
影响因子：
2.8
作者：
Lee, SD
通讯作者：
Lee, SD
影响因子：
--
作者：
El Hidri D;Guesmi A;Najjari A;Cherif H;Ettoumi B;Hamdi C;Boudabous A;Cherif A
通讯作者：
Cherif A
影响因子：
4.4
作者：
Li, Wei;Khullar, Ankush;Gerratana, Barbara
通讯作者：
Gerratana, Barbara