Prefrontal Contribution to Decision-Making under Free-Choice Conditions.
Prefrontal Contribution to Decision-Making under Free-Choice Conditions.
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DOI：
10.3389/fnins.2017.00431
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发表时间：
2017
影响因子：
4.3
通讯作者：
Funahashi S
中科院分区：
文献类型：
--
作者：
Funahashi S
执行功能被认为是多个神经过程的协调操作，允许灵活地完成当前目标。前额叶皮层最重要的功能是执行功能。在前额叶皮层参与的各种执行功能中，决策是最重要的功能之一。虽然前额叶对决策的贡献已经通过各种行为任务进行了研究，但最近使用fMRI的研究表明，前额叶皮层参与了自由选择条件下的决策。由于自由选择条件下的决策是任何一种决策过程的第一阶段，因此我们理解其神经机制是很重要的。虽然很少有研究在猴子执行自由选择任务时研究这个问题，但这些研究表明，当猴子决定随后选择一个特定选项时，对该选项表现出选择性的前额叶神经元在呈现命令性线索之前表现出短暂的激活。进一步的研究表明，这种短暂的增加是由提示呈现前自发放电的不规则波动引起的，这增强了对提示的反应，并使神经元对选项的选择性强度产生偏差。此外，这种偏置效应只在表现出持续延迟期活动的神经元中观察到，这表明这种偏置效应不仅影响动物对即将到来的选择的决定，而且还与前额叶皮层的工作记忆机制有关。
Executive function is thought to be the coordinated operation of multiple neural processes and allows to accomplish a current goal flexibly. The most important function of the prefrontal cortex is the executive function. Among a variety of executive functions in which the prefrontal cortex participates, decision-making is one of the most important. Although the prefrontal contribution to decision-making has been examined using a variety of behavioral tasks, recent studies using fMRI have shown that the prefrontal cortex participates in decision-making under free-choice conditions. Since decision-making under free-choice conditions represents the very first stage for any kind of decision-making process, it is important that we understand its neural mechanism. Although few studies have examined this issue while a monkey performed a free-choice task, those studies showed that, when the monkey made a decision to subsequently choose one particular option, prefrontal neurons showing selectivity to that option exhibited transient activation just before presentation of the imperative cue. Further studies have suggested that this transient increase is caused by the irregular fluctuation of spontaneous firing just before cue presentation, which enhances the response to the cue and biases the strength of the neuron's selectivity to the option. In addition, this biasing effect was observed only in neurons that exhibited sustained delay-period activity, indicating that this biasing effect not only influences the animal's decision for an upcoming choice, but also is linked to working memory mechanisms in the prefrontal cortex.
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影响因子：
3
作者：
Funahashi S
通讯作者：
Funahashi S
影响因子：
3.5
作者：
Funahashi S
通讯作者：
Funahashi S
影响因子：
25
作者：
Donahue CH;Lee D
通讯作者：
Lee D
影响因子：
2.5
作者：
FUSTER, JM
通讯作者：
FUSTER, JM
影响因子：
3.7
作者：
Ding, Long;Gold, Joshua I.
通讯作者：
Gold, Joshua I.