The emergence of a functionally flexible brain during early infancy.
The emergence of a functionally flexible brain during early infancy.
复制标题
DOI：
10.1073/pnas.2002645117
复制
发表时间：
2020-09-22
影响因子：
11.1
通讯作者：
Lin W
中科院分区：
文献类型：
--
作者：
Yin W;Li T;Hung SC;Zhang H;Wang L;Shen D;Zhu H;Mucha PJ;Cohen JR;Lin W
虽然成年人的大脑在功能上是灵活的，但由于缺乏评估婴儿神经灵活性的方法，在婴儿早期出现功能灵活的大脑在很大程度上是未知的。利用多层网络方法的最新进展和一组在生命的前2年接受纵向MRI的典型发育儿童，我们研究了脑神经灵活性的发育特征。一个功能灵活的大脑的时间和空间的出现被揭示。具有高神经灵活性的大脑区域似乎与支持成人认知灵活性处理的核心区域一致，而控制基本大脑功能的大脑区域表现出较低的神经灵活性，这表明在婴儿早期出现了功能灵活的大脑。成年人的大脑在功能上是灵活的，这是一个被认为有助于认知灵活性的独特特征。虽然工具，以评估认知灵活性在婴儿早期缺乏，我们的目的是评估的时空发展特征的“神经灵活性”在生命的第一个2年。五十二个典型的发展中国家的儿童0至2岁的纵向成像高达7次在自然睡眠期间使用静息状态功能MRI。使用滑动窗口方法，MR衍生的神经灵活性（大脑区域在给定时间段内从一个功能模块改变到另一个功能模块的频率的定量测量）被用来评估婴儿早期神经灵活性的时间出现。结果表明，随着年龄的增长，全脑、运动和高阶脑功能网络/区域的神经灵活性显著增加，而视觉区域的神经灵活性表现出时间上的稳定模式，表明神经灵活性的时空不一致性发展特征。此外，3个月龄时初级视觉网络的神经灵活性与5/6岁时评估的认知能力显著负相关。“灵活俱乐部”包括神经灵活性显著高于全脑神经灵活性的大脑区域，与已知控制成人认知灵活性的大脑区域一致，并在与功能中枢和多样化俱乐部区域相比时表现出独特的特征。因此，MR衍生的神经灵活性有可能揭示在婴儿早期发展认知灵活的大脑的潜在神经基质。
While adult brains are known to be functionally flexible, the emergence of a functionally flexible brain during early infancy is largely uncharted due the lack of approaches to assess neural flexibility in infants. Using recent advances of multilayer network approaches and a cohort of typically developing children who underwent longitudinal MRI during the first 2 y of life, we investigated the developmental characteristics of brain neural flexibility. The temporal and spatial emergence of a functionally flexible brain was revealed. Brain regions with high neural flexibility appear consistent with the core regions supporting cognitive flexibility processing in adults, whereas brain regions governing basic brain functions exhibit lower neural flexibility, demonstrating the emergence of functionally flexible brain during early infancy. Adult brains are functionally flexible, a unique characteristic that is thought to contribute to cognitive flexibility. While tools to assess cognitive flexibility during early infancy are lacking, we aimed to assess the spatiotemporal developmental features of “neural flexibility” during the first 2 y of life. Fifty-two typically developing children 0 to 2 y old were longitudinally imaged up to seven times during natural sleep using resting-state functional MRI. Using a sliding window approach, MR-derived neural flexibility, a quantitative measure of the frequency at which brain regions change their allegiance from one functional module to another during a given time period, was used to evaluate the temporal emergence of neural flexibility during early infancy. Results showed that neural flexibility of whole brain, motor, and high-order brain functional networks/regions increased significantly with age, while visual regions exhibited a temporally stable pattern, suggesting spatially and temporally nonuniform developmental features of neural flexibility. Additionally, the neural flexibility of the primary visual network at 3 mo of age was significantly and negatively associated with cognitive ability evaluated at 5/6 y of age. The “flexible club,” comprising brain regions with neural flexibility significantly higher than whole-brain neural flexibility, were consistent with brain regions known to govern cognitive flexibility in adults and exhibited unique characteristics when compared to the functional hub and diverse club regions. Thus, MR-derived neural flexibility has the potential to reveal the underlying neural substrates for developing a cognitively flexible brain during early infancy.
登录
查看更多内容
影响因子：
4.5
作者：
Cheng H;Newman S;Goñi J;Kent JS;Howell J;Bolbecker A;Puce A;O'Donnell BF;Hetrick WP
通讯作者：
Hetrick WP
影响因子：
3.8
作者：
Engel de Abreu PM;Abreu N;Nikaedo CC;Puglisi ML;Tourinho CJ;Miranda MC;Befi-Lopes DM;Bueno OF;Martin R
通讯作者：
Martin R
影响因子：
5.7
作者：
Chen, Qunlin;Yang, Wenjing;Qiu, Jiang
通讯作者：
Qiu, Jiang
影响因子：
4.7
作者：
Casey BJ;Cannonier T;Conley MI;Cohen AO;Barch DM;Heitzeg MM;Soules ME;Teslovich T;Dellarco DV;Garavan H;Orr CA;Wager TD;Banich MT;Speer NK;Sutherland MT;Riedel MC;Dick AS;Bjork JM;Thomas KM;Chaarani B;Mejia MH;Hagler DJ Jr;Daniela Cornejo M;Sicat CS;Harms MP;Dosenbach NUF;Rosenberg M;Earl E;Bartsch H;Watts R;Polimeni JR;Kuperman JM;Fair DA;Dale AM;ABCD Imaging Acquisition Workgroup
通讯作者：
ABCD Imaging Acquisition Workgroup
DOI：
10.1073/pnas.1018985108
发表时间：
2011-05-03
影响因子：
11.1
作者：
Bassett, Danielle S.;Wymbs, Nicholas F.;Grafton, Scott T.
通讯作者：
Grafton, Scott T.