A molecular conundrum involving hypothalamic responses to and roles of long non-coding RNAs following food deprivation.
A molecular conundrum involving hypothalamic responses to and roles of long non-coding RNAs following food deprivation.
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DOI：
10.1016/j.mce.2016.08.028
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发表时间：
2016-12-15
影响因子：
4.1
通讯作者：
Good, Deborah J.
中科院分区：
文献类型：
--
作者：
Jiang, Hao;Good, Deborah J.
关键词：
长链非编码RNA （lncRNAs）是哺乳动物转录组中最不了解的RNA类别之一。然而，它们正在成为转录调控的重要参与者，特别是在复杂的神经系统中。本文综述了lncrna的已知信息及其在内分泌过程中的作用，以及lncrna在大脑和下丘脑神经内分泌中的鲜为人知的信息。研究人员提出了一个“行动呼吁”，利用档案转录组数据来表征下丘脑中差异表达的lncRNA物种。因此，我们分析了lncRNA在正常小鼠和靶向缺失早期螺旋-环-螺旋2基因的小鼠，以及C57Bl/6和129Sv/J小鼠之间的差异表达。最后，提供了研究人员分析自己的数据集或NCBI GEO数据集库中的数据集的策略和方法，希望未来的研究能够揭示lncrna在下丘脑生理反应中的许多新作用，从而一劳永逸地解决这一所谓的“分子难题”。
Long non-coding RNAs (lncRNAs) are one of most poorly understood RNA classes in the mammalian transcriptome. However, they are emerging as important players in transcriptional regulation, especially within the complexity of the nervous system. This review summarizes the known information about lncRNAs, and their roles in endocrine processes, as well as the lesser-known information about lncRNAs in the brain, and in the neuroendocrine hypothalamus. A “call-to-action” is presented for researchers to use archival transcriptome data to characterize differentially expressed lncRNA species within the hypothalamus. In accordance, we analyze for differential-expression of lncRNA between normal mice and mice with a targeted deletion of the nescient helix-loop-helix 2 gene, and between C57Bl/6 and 129Sv/J mice. Finally, strategies and approaches for researchers to analyze their own datasets or those on the NCBI GEO datasets repository are provided, in hopes that future studies will reveal many new roles for lncRNAs in hypothalamic physiological responses, solving this so-called “molecular conundrum” once and for all.
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脂肪组织转录组的从头重建揭示了棕色脂肪细胞发育的长无编码RNA调节剂。
影响因子：
29
作者：
Alvarez-Dominguez JR;Bai Z;Xu D;Yuan B;Lo KA;Yoon MJ;Lim YC;Knoll M;Slavov N;Chen S;Peng C;Lodish HF;Sun L
通讯作者：
Sun L
影响因子：
56.9
作者：
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通讯作者：
Hayashizaki, Y
影响因子：
11.4
作者：
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通讯作者：
Calegari, Federico
DOI：
10.1016/j.bbacli.2015.09.001
发表时间：
2015-12
期刊：
BBA clinical
影响因子：
--
作者：
Carter G;Miladinovic B;Patel AA;Deland L;Mastorides S;Patel NA
通讯作者：
Patel NA
影响因子：
3.7
作者：
Ellis BC;Molloy PL;Graham LD
通讯作者：
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