Stronger influence of maternal than paternal obesity on infant and early childhood body mass index: the Fels Longitudinal Study.
Stronger influence of maternal than paternal obesity on infant and early childhood body mass index: the Fels Longitudinal Study.
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DOI：
10.1111/j.2047-6310.2012.00100.x
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发表时间：
2013-06
影响因子：
3.8
通讯作者：
Demerath EW
中科院分区：
文献类型：
--
作者：
Linabery AM;Nahhas RW;Johnson W;Choh AC;Towne B;Odegaard AO;Czerwinski SA;Demerath EW
父母肥胖会影响婴儿的体型。为了全面了解它们对婴儿肥胖的相对影响，在FELS纵向研究参与者中，比较了母亲和父亲的体重指数类别(正常：≤25 kg/m2，超重：25-lt；30 kg/m2，肥胖：≥30 kg/m2)与婴儿体重指数的关系。从1928-2008年出生的912名欧洲裔美国儿童中获得了出生3.5岁的9个系列体重和长度测量的中位数。采用多变量混合效应回归分析，评价母亲与父亲的BMI状态对婴儿BMI生长曲线的贡献。三次样条法模型还包括父母协变量、婴儿性别、年龄和出生变量，以及与孩子年龄的交互作用。婴儿体重指数曲线在三个母亲的体重指数类别中存在显著差异(POVERALL<；0.0001)，肥胖母亲的子女在出生时和1.5-3.5年期间的平均体重指数高于超重和正常体重母亲的子女(P≤0.02)。肥胖母亲和正常体重母亲的子女出生时的平均差异(0.80 kg/m2，P=0.0009)和2-3.5年间的平均差异(0.70-0.8 kg/m2，P=0.0001)相似。肥胖父亲的婴儿的BMI增长曲线也不同于正常体重父亲的婴儿(P=0.02)。婴儿体重指数与母亲肥胖的关系总体上比父亲肥胖更强(P<；0.0001)；出生时(1.11 kg/m2，P=0.006)和2-3岁时(0.62 kg/m2，P3岁=0.02)有显著差异。在出生时和婴儿后期，母亲的BMI对BMI增长的影响比父亲的BMI更大，这表明育龄妇女的体重控制可能对防止婴儿BMI过高特别有益。
Parental obesity influences infant body size. To fully characterize their relative effects on infant adiposity, associations between maternal and paternal body mass index (BMI) category (normal: ≤25 kg/m2, overweight: 25–<30 kg/m2, obese: ≥30 kg/m2) and infant BMI were compared in Fels Longitudinal Study participants. A median of 9 serial weight and length measures from birth-3.5 years were obtained from 912 European American children born in 1928–2008. Using multivariable mixed effects regression, contributions of maternal versus paternal BMI status to infant BMI growth curves were evaluated. Cubic spline models also included parental covariates, infant sex, age, and birth variables, and interactions with child’s age. Infant BMI curves were significantly different across the three maternal BMI categories (POverall<0.0001), and offspring of obese mothers had greater mean BMI at birth and between 1.5–3.5 years than those of over- and normal weight mothers (P≤0.02). Average differences between offspring of obese and normal weight mothers were similar at birth (0.8 kg/m2, P=0.0009) and between 2–3.5 years (0.7–0.8 kg/m2, P<0.0001). Infants of obese fathers also had BMI growth curves distinct from those of normal weight fathers (P=0.02). Infant BMI was more strongly associated with maternal than paternal obesity overall (P<0.0001); significant differences were observed at birth (1.11 kg/m2, P=0.006) and from 2–3 years (0.62 kg/m2, P3years=0.02). At birth and in later infancy, maternal BMI has a stronger influence on BMI growth than paternal BMI, suggesting weight control in reproductive age women may be of particular benefit for preventing excess infant BMI.
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