Influenza-infected neutrophils within the infected lungs act as antigen presenting cells for anti-viral CD8(+) T cells.
Influenza-infected neutrophils within the infected lungs act as antigen presenting cells for anti-viral CD8(+) T cells.
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DOI：
10.1371/journal.pone.0046581
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Braciale TJ
中科院分区：
文献类型：
--
作者：
Hufford MM;Richardson G;Zhou H;Manicassamy B;García-Sastre A;Enelow RI;Braciale TJ
甲型流感病毒（IAV）是全球呼吸道疾病的主要原因。对IAV感染应答的抗病毒CD8+ T淋巴细胞被认为通过直接细胞溶解消除病毒感染的细胞，但也可能通过在识别病毒抗原展示细胞后释放促炎介质而导致肺部炎症和组织损伤。我们以前已经证明，IAV抗原表达造血来源的炎症细胞内感染的肺结节作为抗原呈递细胞（APC）浸润效应CD8+ T淋巴细胞，然而，光谱的炎症细胞类型能够作为APC没有确定。在这里，我们证明，病毒抗原显示中性粒细胞浸润IAV感染的肺是一个重要的细胞类型，能够作为APC的效应CD8+ T淋巴细胞在感染的肺和中性粒细胞表达病毒抗原的结果，直接感染IAV表现出最有效的APC活性。我们的研究结果表明，除了在诱导对IAV的先天性免疫应答、病毒清除和肺损伤的发展中的作用外，中性粒细胞还可以在感染的肺组织中充当抗病毒效应CD8+ T细胞的APC。
Influenza A virus (IAV) is a leading cause of respiratory tract disease worldwide. Anti-viral CD8+ T lymphocytes responding to IAV infection are believed to eliminate virally infected cells by direct cytolysis but may also contribute to pulmonary inflammation and tissue damage via the release of pro-inflammatory mediators following recognition of viral antigen displaying cells. We have previously demonstrated that IAV antigen expressing inflammatory cells of hematopoietic origin within the infected lung interstitium serve as antigen presenting cells (APC) for infiltrating effector CD8+ T lymphocytes; however, the spectrum of inflammatory cell types capable of serving as APC was not determined. Here, we demonstrate that viral antigen displaying neutrophils infiltrating the IAV infected lungs are an important cell type capable of acting as APC for effector CD8+ T lymphocytes in the infected lungs and that neutrophils expressing viral antigen as a result of direct infection by IAV exhibit the most potent APC activity. Our findings suggest that in addition to their suggested role in induction of the innate immune responses to IAV, virus clearance, and the development of pulmonary injury, neutrophils can serve as APCs to anti-viral effector CD8+ T cells within the infected lung interstitium.
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影响因子：
15.3
作者：
Bainton, D F;Ullyot, J L;Farquhar, M G
通讯作者：
Farquhar, M G
DOI：
10.1084/jem.20101850
发表时间：
2011-01-17
期刊：
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作者：
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通讯作者：
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Katsikis, Peter D.
影响因子：
4.4
作者：
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通讯作者：
Denkers, EY