Pancreatic cancer cachexia: a review of mechanisms and therapeutics.

Pancreatic cancer cachexia: a review of mechanisms and therapeutics.
复制标题

DOI:
10.3389/fphys.2014.00088
复制
发表时间:
2014
影响因子:
4
通讯作者:
Hendifar AE
Hendifar AE
中科院分区:
医学2区
文献类型:
--
作者:
Tan CR;Yaffee PM;Jamil LH;Lo SK;Nissen N;Pandol SJ;Tuli R;Hendifar AE

文献摘要

参考文献

被引文献

相似文献

在过去的十年中,我们对胰腺癌相关恶病质的病理生理学有了新的认识。不幸的是,其治疗是复杂的,仍然是一个挑战。胰腺癌恶病质是一种多因素综合征,其特征是在厌食症的情况下发生脂肪组织和骨骼肌失代偿,导致进行性功能障碍。本文将回顾目前的概念,胰腺癌恶病质,其评估和病理生理,以及目前和未来的治疗。胰腺癌恶病质的成功治疗可能需要多模式方法,包括营养支持和联合药物干预。
Over the last decade, we have gained new insight into the pathophysiology of cachexia associated with pancreatic cancer. Unfortunately, its treatment is complex and remains a challenge. Pancreatic cancer cachexia is a multifactorial syndrome characterized by uncompensated adipose tissue and skeletal muscle loss in the setting of anorexia that leads to progressive functional impairment. This paper will review the current concepts of pancreatic cancer cachexia, its assessment and pathophysiology as well as current and future treatments. The successful management of pancreatic cancer cachexia will likely require a multimodal approach that includes nutritional support and combination pharmaceutical interventions.
DOI: 10.1038/sj.bjc.6690654
发表时间: 1999-09
影响因子: 8.8
作者:
Barber, MD;Ross, JA;Voss, AC;Tisdale, MJ;Fearon, KCH
通讯作者: Fearon, KCH
DOI: 10.1007/s00520-004-0746-7
发表时间: 2005-04-01
影响因子: 3.1
作者:
Bauer, JD;Capra, S
通讯作者: Capra, S
DOI: 10.1016/j.jamda.2010.02.012
发表时间: 2011-01-01
影响因子: 7.6
作者:
Chasen, Martin;Hirschman, Shalom Z.;Bhargava, Ravi
通讯作者: Bhargava, Ravi
蛋白质分解诱导因子在胃肠道癌症患者的肿瘤中表达,并与体重减轻相关
DOI: 10.1054/bjoc.2001.1830
发表时间: 2001-06-15
影响因子: 8.8
作者:
Cabal-Manzano,R;Bhargava,P;Wainer,IW
通讯作者: Wainer,IW
DOI: 10.1186/1471-2407-9-255
发表时间: 2009-07-28
期刊: BMC cancer
影响因子: 3.8
作者:
Bachmann J;Ketterer K;Marsch C;Fechtner K;Krakowski-Roosen H;Büchler MW;Friess H;Martignoni ME
通讯作者: Martignoni ME