Pancreatic cancer cachexia: a review of mechanisms and therapeutics.
Pancreatic cancer cachexia: a review of mechanisms and therapeutics.
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DOI:
10.3389/fphys.2014.00088
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发表时间:
2014
影响因子:
4
通讯作者:
Hendifar AE
中科院分区:
文献类型:
--
作者:
Tan CR;Yaffee PM;Jamil LH;Lo SK;Nissen N;Pandol SJ;Tuli R;Hendifar AE
Over the last decade, we have gained new insight into the pathophysiology of cachexia associated with pancreatic cancer. Unfortunately, its treatment is complex and remains a challenge. Pancreatic cancer cachexia is a multifactorial syndrome characterized by uncompensated adipose tissue and skeletal muscle loss in the setting of anorexia that leads to progressive functional impairment. This paper will review the current concepts of pancreatic cancer cachexia, its assessment and pathophysiology as well as current and future treatments. The successful management of pancreatic cancer cachexia will likely require a multimodal approach that includes nutritional support and combination pharmaceutical interventions.
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