The effect of an oral nutritional supplement enriched with fish oil on weight-loss in patients with pancreatic cancer.
The effect of an oral nutritional supplement enriched with fish oil on weight-loss in patients with pancreatic cancer.
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富含鱼油的口服营养补充剂对胰腺癌患者减肥的影响。
DOI：
10.1038/sj.bjc.6690654
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发表时间：
1999-09
影响因子：
8.8
通讯作者：
Fearon, KCH
中科院分区：
文献类型：
--
作者：
Barber, MD;Ross, JA;Voss, AC;Tisdale, MJ;Fearon, KCH
关键词：
先前的研究表明，口服二十碳五烯酸（EPA）可以稳定晚期胰腺癌患者的体重。本研究的目的是确定 EPA 与传统口服营养补充剂的组合是否可以使这些患者体重增加。二十名患有不可切除的胰腺癌的患者被要求在正常食物摄入量之外每天食用两罐富含鱼油的营养补充剂。每罐含有 310 kcal、16.1 g 蛋白质和 1.09 g EPA。对患者的体重、身体成分、饮食摄入量、静息能量消耗（REE）和体能状态进行评估。患者第 1 天平均消耗 1.9 罐。所有患者的基线体重均以每月 2.9 kg−1 的中位速度减轻。服用富含鱼油的补充剂后，患者在第 3 周（中位数 1 kg，P = 0.024）和 7 周（中位数 2 kg，P = 0.033）体重均显着增加。膳食摄入量显着增加近 400 kcal day−1 (P = 0.002)。每公斤体重和每公斤瘦体重的稀土元素显着下降。三周后，体能状态和食欲显着改善。与之前针对减肥癌症患者口服传统营养补充剂的研究相比，这项研究表明，富含 EPA 的补充剂可能会逆转晚期胰腺癌的恶病质。 © 1999 癌症研究运动
Previous studies have suggested that administration of oral eicosapentaenoic acid (EPA) will stabilize weight in patients with advanced pancreatic cancer. The aim of the present study was to determine if a combination of EPA with a conventional oral nutritional supplement could produce weight gain in these patients. Twenty patients with unresectable pancreatic adenocarcinoma were asked to consume two cans of a fish oil-enriched nutritional supplement per day in addition to their normal food intake. Each can contained 310 kcal, 16.1 g protein and 1.09 g EPA. Patients were assessed for weight, body composition, dietary intake, resting energy expenditure (REE) and performance status. Patients consumed a median of 1.9 cans day−1. All patients were losing weight at baseline at a median rate of 2.9 kg month−1. After administration of the fish oil-enriched supplement, patients had significant weight-gain at both 3 (median 1 kg, P = 0.024) and 7 weeks (median 2 kg, P = 0.033). Dietary intake increased significantly by almost 400 kcal day−1 (P = 0.002). REE per kg body weight and per kg lean body mass fell significantly. Performance status and appetite were significantly improved at 3 weeks. In contrast to previous studies of oral conventional nutritional supplements in weight-losing cancer patients, this study suggests that an EPA-enriched supplement may reverse cachexia in advanced pancreatic cancer. © 1999 Cancer Research Campaign
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影响因子：
8.8
作者：
Falconer JS;Ross JA;Fearon KC;Hawkins RA;O'Riordain MG;Carter DC
通讯作者：
Carter DC
DOI：
10.1080/01635588209513746
发表时间：
1982-01-01
期刊：
Nutrition and cancer
影响因子：
--
作者：
Cohn, S H;Vartsky, D;Ellis, K J
通讯作者：
Ellis, K J
影响因子：
2.9
作者：
OVESEN, L;HANNIBAL, J;MORTENSEN, EL
通讯作者：
MORTENSEN, EL
影响因子：
9
作者：
FALCONER, JS;FEARON, KCH;CARTER, DC
通讯作者：
CARTER, DC
影响因子：
6
作者：
HANNAN, WJ;COWEN, SJ;DEBEAU, A
通讯作者：
DEBEAU, A