Mechanistic insights into selective autophagy pathways: lessons from yeast.
Mechanistic insights into selective autophagy pathways: lessons from yeast.
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DOI：
10.1038/nrm.2016.74
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发表时间：
2016-09
期刊：
影响因子：
--
通讯作者：
Subramani S
中科院分区：
文献类型：
--
作者：
Farré JC;Subramani S
自噬作为一个研究领域迅速发展，因为它的进化保守性，细胞内货物的多样性，降解和回收的机制，以及它与人类健康和疾病的生理相关性。这种自噬过程最初被认为是真核细胞在应对压力时降解和回收大分子的非选择性机制;我们现在知道各种细胞成分以及病原体也可以进行选择性自噬。与非选择性自噬相反，选择性自噬途径依赖于大量的选择性自噬受体（SAR），其识别并指导细胞内蛋白质聚集体、细胞器和病原体进行特异性降解。虽然SAR本身并不高度保守，但它们的作用模式以及激活和调节它们的信号级联是高度保守的。最近的酵母研究为选择性自噬途径提供了新的机制见解，揭示了如何标记和靶向选择性降解各种货物的原则。
Autophagy has burgeoned rapidly as a field of study because of its evolutionary conservation, the diversity of intracellular cargoes degraded and recycled by this machinery the mechanisms involved, as well as its physiological relevance to human health and disease. This self-eating process was initially viewed as a non-selective mechanism used by eukaryotic cells to degrade and recycle macromolecules in response to stress; we now know that various cellular constituents, as well as pathogens, can also undergo selective autophagy. In contrast to non-selective autophagy, selective autophagy pathways rely on a plethora of selective autophagy receptors (SARs) that recognize and direct intracellular protein aggregates, organelles and pathogens for specific degradation. Although SARs themselves are not highly conserved, their modes of action and the signalling cascades that activate and regulate them are. Recent yeast studies have provided novel mechanistic insights into selective autophagy pathways, revealing principles of how various cargoes can be marked and targeted for selective degradation.
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DOI：
10.1073/pnas.1404171111
发表时间：
2014-09-30
影响因子：
11.1
作者：
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通讯作者：
Kung, Hsing-Jien
影响因子：
3.3
作者：
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通讯作者：
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影响因子：
3.3
作者：
Ano, Y;Hattori, T;Sakai, Y
通讯作者：
Sakai, Y
影响因子：
13.3
作者：
Hara, Taichi;Mizushima, Noboru
通讯作者：
Mizushima, Noboru
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影响因子：
7.8
作者：
He, Congcong;Song, Hui;Yorimitsu, Tomohiro;Monastyrska, Iryna;Yen, Wei-Lien;Legakis, Julie E;Klionsky, Daniel J
通讯作者：
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