Serum free testosterone and asthma, asthma hospitalisations and lung function in British adults.
Serum free testosterone and asthma, asthma hospitalisations and lung function in British adults.
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DOI：
10.1136/thoraxjnl-2020-214875
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发表时间：
2020-10
期刊：
影响因子：
10
通讯作者：
Celedon JC
中科院分区：
文献类型：
--
作者：
Han YY;Yan Q;Yang G;Chen W;Forno E;Celedon JC
我们研究了老年人血清游离睾酮与哮喘、喘息、哮喘住院和肺功能之间的关系。横断面研究英国 2006 年至 2010 年招募的 256,419 名 40 至 69 岁成年人使用多变量逻辑回归或线性回归分析游离睾酮和医生诊断的哮喘、当前喘息、哮喘住院和肺功能测量，并根据血清雌二醇、吸烟状况和其他协变量进行调整。游离睾酮水平高于最低四分位数 (Q1) 与女性（Q4 [最高四分位] 与 Q1 的调整比值比 [aOR] 与 Q1=0.67，95% 置信区间 [CI]=0.64–0.71）和男性（Q4 与 Q1 的 aOR=0.87，95% CI=0.82-0.91）的哮喘发病率较低显着相关。在哮喘受试者中，高于 Q1 的游离睾酮水平与女性当前喘息的几率较低显着相关（aOR 范围 = 0.78 至 0.87），而 Q4 中的游离睾酮水平与男性当前喘息的几率较低相关（Q4 与 Q1 的 aOR = 0.86，95% CI = 0.77-0.95）。在患有哮喘的女性中，第四季度的游离睾酮水平也与≥1次哮喘住院的几率较低相关。在男性中，游离睾酮与 FEV1 和 FVC 呈正相关。在女性中，游离睾酮与用力肺活量呈负相关且微弱相关。在一项针对英国成年人的大型研究中，游离睾酮水平升高与女性和男性患哮喘和当前喘息的几率较低、女性因哮喘住院的几率较低以及男性较高的 FEV1 和 FVC 相关。
We examined the relation between serum free testosterone and asthma, wheeze, asthma hospitalizations, and lung function in older adults. Cross-sectional study United Kingdom 256,419 adults aged 40 to 69 years, recruited from 2006 to 2010 Multivariable logistic or linear regression was used for the analysis of free testosterone and physician-diagnosed asthma, current wheeze, asthma hospitalizations, and lung function measures, which was adjusted for serum estradiol, smoking status, and other covariates. Free testosterone levels above the lowest quartile (Q1) were significantly associated with lower odds of asthma in both women (adjusted odds ratio [aOR] for Q4 [the highest quartile] vs. Q1=0.67, 95% confidence interval [CI]=0.64–0.71) and men (aOR for Q4 vs. Q1=0.87, 95% CI=0.82-0.91). Among subjects with asthma, free testosterone levels above Q1 were significantly associated with lower odds of current wheeze in women (aOR range=0.78 to 0.87), and free testosterone levels in Q4 were associated with lower odds of current wheeze in men (aOR for Q4 vs Q1=0.86, 95% CI=0.77-0.95). Among women with asthma, free testosterone levels in Q4 were also associated with lower odds of ≥1 asthma hospitalization. Among men, free testosterone was positively associated with FEV1 and FVC. Among women, free testosterone was negatively and weakly associated with FVC. In a large study of British adults, elevated free testosterone levels are associated with lower odds of asthma and current wheeze in women and men, lower odds of asthma hospitalizations in women, and higher FEV1 and FVC in men.
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