Adult Neurogenesis in Teleost Fish
Adult Neurogenesis in Teleost Fish
复制标题
硬骨鱼成体神经发生
DOI：
--
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
G. Zupanc
中科院分区：
文献类型：
--
作者：
G. Zupanc
自20世纪60年代以来，人们一直在研究硬骨鱼脑中的成体神经发生。这些研究表明，在几十个脑区的有丝分裂活动和细胞增殖的相对速度比成年哺乳动物大脑高10-100倍。新细胞的来源是不同的神经增殖区的干细胞，这些干细胞产生神经元和神经胶质细胞。根据大脑区域的不同，年轻细胞要么居住在它们起源的增殖区附近，要么迁移到特定的靶区域。在迁移过程中，它们由放射状胶质纤维引导。大约一半的年轻细胞在其生命的最初几周内经历凋亡性细胞死亡;另一半长期存在。这种新细胞不断添加到旧细胞群体中导致大脑的永久生长。硬骨鱼类成体神经发生的一个主要功能似乎是确保中枢神经系统神经元与外周感觉受体细胞或肌纤维的数量匹配。神经发生在大脑修复中也起着核心作用，它通过新产生的细胞取代因损伤而失去的细胞。通过蛋白质组学分析对再生相关蛋白的大规模鉴定揭示了新细胞形成所必需的细胞骨架蛋白，参与细胞增殖、细胞运动、神经保护和能量代谢的蛋白质，以及可能充当转录调节因子的锌指蛋白。
Adult neurogenesis in the brain of teleost fish has been studied since the 1960s. These investigations have demonstrated mitotic activity in dozens of brain areas and relative rates of cell proliferation 10–100 times higher than in the adult mammalian brain. The source of the new cells are stem cells in distinct proliferation zones, which give rise to both neurons and glial cells. Depending on the brain region, the young cells either reside in close vicinity to the proliferation zone from which they originate, or they migrate long distance to specific target areas. During migration, they are guided by radial glial fibers. Approximately half the young cells undergo apoptotic cell death within the first few weeks of their life; the other half persist long term. This continuous addition of new cells to the population of older cells leads to a permanent growth of the brain. A major function of adult neurogenesis in teleosts appears to be to ensure numerical matching of neurons in the central nervous system and sensory receptors cells or muscle fibers in the periphery. Neurogenesis also plays a central role in brain repair by replacing cells lost to injury by newly generated ones. Large-scale identification of regeneration-associated proteins by proteome analysis has revealed cytoskeletal proteins essential for the formation of new cells, proteins involved in cell proliferation, cellular motility, neuroprotection, and energy metabolism, as well as a zinc finger protein that may act as a transcriptional regulator.
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DOI：
10.1016/0165-3806(96)00069-7
发表时间：
1996-10-23
期刊：
DEVELOPMENTAL BRAIN RESEARCH
影响因子：
--
作者：
Herrup, K;ShojaeianZanjani, H;Mariani, J
通讯作者：
Mariani, J
DOI：
10.1073/pnas.88.23.10540
发表时间：
1991-12-01
影响因子：
11.1
作者：
SMITH, CD;CARNEY, JM;MARKESBERY, WR
通讯作者：
MARKESBERY, WR
DOI：
10.1002/neu.480230209
发表时间：
1992-03-01
期刊：
JOURNAL OF NEUROBIOLOGY
影响因子：
--
作者：
HITCHCOCK, PF;MYHR, KJL;JONES, DD
通讯作者：
JONES, DD
DOI：
10.1073/pnas.87.13.5144
发表时间：
1990-07-01
影响因子：
11.1
作者：
OLIVER, CN;STARKEREED, PE;FLOYD, RA
通讯作者：
FLOYD, RA
再生硬骨鱼脊髓组织培养物中室管膜衍生细胞神经元的分子分化。
影响因子：
2.9
作者：
Anderson,MJ;Waxman,SG;Lee,YL;Eng,LF
通讯作者：
Eng,LF