A bridge between the aminoacylation and editing domains of leucyl-tRNA synthetase is crucial for its synthetic activity.

A bridge between the aminoacylation and editing domains of leucyl-tRNA synthetase is crucial for its synthetic activity.
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亮氨酰-tRNA 合成酶的氨酰化和编辑域之间的桥梁对其合成活性至关重要

DOI:
10.1261/rna.044404.114
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发表时间:
2014-09
期刊:
RNA (New York, N.Y.)
影响因子:
--
通讯作者:
Wang ED
Wang ED
中科院分区:
其他
文献类型:
--
作者:
Huang Q;Zhou XL;Hu QH;Lei HY;Fang ZP;Yao P;Wang ED

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本文研究了连接亮氨酰-tRNA 合成酶的氨酰化和编辑域的氨基酸的作用。这些氨基酸的删除导致编辑活性的氨酰化保留完全丧失。这些结果表明氨酰化结构域和编辑结构域之间的桥梁对于合成酶的功能至关重要。
This paper examines the role of amino acids connecting the aminoacylation and editing domains of leucyl-tRNA synthetase. Deletion of these amino acids resulted in complete loss of aminoacylation retention of editing activity. These results indicate that the bridge between the aminoacylation domain and editing domain is crucial for the function of the synthetase.
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