A bridge between the aminoacylation and editing domains of leucyl-tRNA synthetase is crucial for its synthetic activity.
A bridge between the aminoacylation and editing domains of leucyl-tRNA synthetase is crucial for its synthetic activity.
复制标题
亮氨酰-tRNA 合成酶的氨酰化和编辑域之间的桥梁对其合成活性至关重要
DOI:
10.1261/rna.044404.114
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发表时间:
2014-09
期刊:
影响因子:
--
通讯作者:
Wang ED
中科院分区:
文献类型:
--
作者:
Huang Q;Zhou XL;Hu QH;Lei HY;Fang ZP;Yao P;Wang ED
This paper examines the role of amino acids connecting the aminoacylation and editing domains of leucyl-tRNA synthetase. Deletion of these amino acids resulted in complete loss of aminoacylation retention of editing activity. These results indicate that the bridge between the aminoacylation domain and editing domain is crucial for the function of the synthetase.
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