High-speed intravascular photoacoustic imaging of lipid-laden atherosclerotic plaque enabled by a 2-kHz barium nitrite raman laser.

High-speed intravascular photoacoustic imaging of lipid-laden atherosclerotic plaque enabled by a 2-kHz barium nitrite raman laser.
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DOI:
10.1038/srep06889
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发表时间:
2014-11-04
期刊:
影响因子:
4.6
通讯作者:
Cheng JX
Cheng JX
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Wang P;Ma T;Slipchenko MN;Liang S;Hui J;Shung KK;Roy S;Sturek M;Zhou Q;Chen Z;Cheng JX

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动脉壁内的脂质沉积是斑块易损性的关键指标。血管内光声(IVPA)导管被认为是一种用于量化动脉壁内脂质含量的有前景的设备。到目前为止,由于缺乏适用于分子泛音振动高速激发的激光源,IVPA系统的成像速度较慢(约每帧50秒)。在此,我们报道通过一种定制的、由2 - kHz主振荡功率放大器(MOPA)泵浦的亚硝酸钡[Ba(NO3)2]拉曼激光,将IVPA成像速度提高了两个数量级,达到每帧1.0秒。这一进展缩小了将IVPA技术转化到临床应用的差距。
Lipid deposition inside the arterial wall is a key indicator of plaque vulnerability. An intravascular photoacoustic (IVPA) catheter is considered a promising device for quantifying the amount of lipid inside the arterial wall. Thus far, IVPA systems suffered from slow imaging speed (~50 s per frame) due to the lack of a suitable laser source for high-speed excitation of molecular overtone vibrations. Here, we report an improvement in IVPA imaging speed by two orders of magnitude, to 1.0 s per frame, enabled by a custom-built, 2-kHz master oscillator power amplifier (MOPA)-pumped, barium nitrite [Ba(NO3)2] Raman laser. This advancement narrows the gap in translating the IVPA technology to the clinical setting.
动脉粥样硬化的炎症。
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发表时间: 2012-09
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