The Effects of Laparoscopic Sleeve Gastrectomy on Obesity-Related Hypertriglyceridemia-Induced Acute Pancreatitis
The Effects of Laparoscopic Sleeve Gastrectomy on Obesity-Related Hypertriglyceridemia-Induced Acute Pancreatitis
复制标题
腹腔镜袖状胃切除术对肥胖相关高甘油三酯血症诱发的急性胰腺炎的影响
DOI：
10.1007/s11695-018-3446-y
复制
发表时间：
2018-08
期刊：
影响因子：
2.9
通讯作者：
任亦星
中科院分区：
文献类型：
--
作者：
宋永砚;邓欢;周杰;孙骥;张小明;任亦星
高甘油三酯血症诱发的急性胰腺炎(HTG-AP)是一个重要的临床问题，与非HTG-AP相比具有复发率高的特点。目的探讨腹腔镜袖状胃切除术(LSG)对肥胖性HTG-AP的影响。方法对29例肥胖性HTG-AP患者，根据患者意愿采用常规治疗或LSG手术治疗。观察两组患者治疗前、治疗后3、6、9、12个月4个时点的临床资料及AP复发率。结果29例患者中，28例(常规治疗19例，LSG手术9例)完成12个月随访。当患者进入重症监护病房时，临床数据和AP的严重程度评分在基线时具有可比性。LSG组术后体重明显下降(总体重下降26.87 ± 1.44%，超重下降79.56 ± 1.37%)，甘油三酯下降(由15.77 ± 1.02降至1.36 ± 0.09)，术后12个月无复发。常规治疗组体重无明显变化，但甘油三酯显著下降(从17.34 ± 1.29降至8.25 ± 1.12)，更重要的是，47.4%的患者在治疗后12个月内至少复发一次AP。需要进一步的随机研究来标准化这种治疗方法。
BackgroundHypertriglyceridemia-induced acute pancreatitis (HTG-AP) is a significant clinical problem and is characterized by high recurrence rate compared with non-HTG-AP. The objective of this study was to investigate the effects of laparoscopic sleeve gastrectomy (LSG) on obesity-related HTG-AP.MethodsTwenty-nine patients with obesity-related HTG-AP were admitted to our hospital and treated with the conventional therapy or LSG surgery according to the wishes of patients. Clinical data and the recurrence rate of AP were collected at baseline and at four different time points (3, 6, 9, and 12 months) after the treatments for all patients.ResultsOf the 29 patients, 28 patients (19 patients with conventional therapy and 9 patients with LSG surgery) completed the 12-month follow-up. Clinical data and the severity scores of AP were comparable at baseline when the patients were admitted to the intensive care unit. The LSG group experienced a large weight loss (percent total weight loss, 26.87 ± 1.44%; percent excess weight loss, 79.56 ± 1.37%) and triglyceride reduction (from 15.77 ± 1.02 to 1.36 ± 0.09 mmol/L), and no recurrence was observed at 12 months after the surgery. In the conventional treatment group, however, body weight was not changed although triglyceride was significantly decreased (from 17.34 ± 1.29 to 8.25 ± 1.12 mmol/L), and more importantly, 47.4% of the patients had at least one recurrence of AP in 12 months after the treatment.ConclusionsLSG might be an effective way to cure obesity-related HTG-induced AP since it prevents the recurrence of this disease. Further randomized studies will be needed to standardize this way of treatment.
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DOI：
10.1016/j.metabol.2017.01.030
发表时间：
2017-05
期刊：
Metabolism: clinical and experimental
影响因子：
--
作者：
Hagman DK;Larson I;Kuzma JN;Cromer G;Makar K;Rubinow KB;Foster-Schubert KE;van Yserloo B;Billing PS;Landerholm RW;Crouthamel M;Flum DR;Cummings DE;Kratz M
通讯作者：
Kratz M
影响因子：
0.7
作者：
Hammond, Drayton A;Finlay, Laura
通讯作者：
Finlay, Laura
影响因子：
3.6
作者：
Sztefko, K;Panek, J
通讯作者：
Panek, J
影响因子：
16.9
作者：
Golomb, Inbal;Ben David, Matan;Keidar, Andrei
通讯作者：
Keidar, Andrei
影响因子：
2.6
作者：
Cheng-Chiao Huang;Weu Wang;R. Chen;P. Wei;C. Tzao;Ping-Ling Chen
通讯作者：
Cheng-Chiao Huang;Weu Wang;R. Chen;P. Wei;C. Tzao;Ping-Ling Chen