Specifically altered brain responses to threat in generalized anxiety disorder relative to social anxiety disorder and panic disorder.
Specifically altered brain responses to threat in generalized anxiety disorder relative to social anxiety disorder and panic disorder.
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DOI：
10.1016/j.nicl.2016.09.023
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发表时间：
2016
影响因子：
4.2
通讯作者：
Straube, Thomas
中科院分区：
文献类型：
--
作者：
Buff, Christine;Brinkmann, Leonie;Neumeister, Paula;Feldker, Katharina;Heitmann, Carina;Gathmann, Bettina;Andor, Tanja;Straube, Thomas
尽管做出了相当大的努力，但对广泛性焦虑症(GAD)患者特有的高反应性威胁处理的神经生物学基础仍然知之甚少。目前的功能磁共振成像(FMRI)研究旨在通过将GAD患者与健康对照组(HC)、社交焦虑症(SAD)和惊恐障碍(PD)患者进行比较，来描绘GAD患者在即时威胁处理过程中的特定大脑活动。使用事件相关功能磁共振成像研究威胁图片和中性图片的大脑激活和功能连接模式。样品由21个GAD、21个PD、21个SAD和21个HC组成。在扣带回皮质、岛背/额盖(DAI/FO)和后背外侧前额叶皮质(DlPFC)，GAD特异性地增强了对威胁图片的反应。将这些效应定义为种子区域，我们检测到GAD特异性增强了dlPFC后部与前额叶腹外侧皮层、扣带回与杏仁核、扣带回与前岛之间的威胁与中性图片的功能连接，以及DAI/FO与dlPFC中部之间的功能连接降低。这一发现为GAD特有的高反应威胁处理的神经关联提供了第一个证据，可能反映了夸大的威胁敏感性、不适应的评估和注意力分配过程。跨多重焦虑症的威胁处理研究GAD特异性威胁相关改变的首次神经证据GAD特异性改变主要位于前额叶皮质改变提示威胁敏感性被夸大
Despite considerable effort, the neurobiological underpinnings of hyper-responsive threat processing specific to patients suffering from generalized anxiety disorder (GAD) remain poorly understood. The current functional magnetic resonance imaging (fMRI) study aims to delineate GAD-specific brain activity during immediate threat processing by comparing GAD patients to healthy controls (HC), to social anxiety disorder (SAD) and to panic disorder (PD) patients. Brain activation and functional connectivity patterns to threat vs. neutral pictures were investigated using event-related fMRI. The sample consisted of 21 GAD, 21 PD, 21 SAD and 21 HC. GAD-specific elevated activity to threat vs. neutral pictures was found in cingulate cortex, dorsal anterior insula/frontal operculum (daI/FO) and posterior dorsolateral prefrontal cortex (dlPFC). Defining these effects as seed regions, we detected GAD-specific increased functional connectivity to threat vs. neutral pictures between posterior dlPFC and ventrolateral prefrontal cortex, between cingulate cortex and amygdala, between cingulate cortex and anterior insula, as well as decreased functional connectivity between daI/FO and mid-dlPFC. The findings present the first evidence for GAD-specific neural correlates of hyper-responsive threat processing, possibly reflecting exaggerated threat sensitivity, maladaptive appraisal and attention-allocation processes. Threat processing investigation across multiple anxiety disorders First neural evidence of GAD-specific threat-related alterations GAD-specific alterations primarily located in prefrontal cortex Alterations are suggestive of exaggerated threat sensitivity
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影响因子：
19.9
作者：
Etkin, Amit;Egner, Tobias;Kalisch, Raffael
通讯作者：
Kalisch, Raffael
影响因子：
2.3
作者：
Hoehn-Saric, R;Schlund, MW;Wong, SHY
通讯作者：
Wong, SHY
影响因子：
6.6
作者：
Fonzo, Gregory A.;Ramsawh, Holly J.;Flagan, Taru M.;Sullivan, Sarah G.;Simmons, Alan N.;Paulus, Martin P.;Stein, Murray B.
通讯作者：
Stein, Murray B.
影响因子：
6.9
作者：
Fresco, DM;Coles, ME;Goetz, D
通讯作者：
Goetz, D
DOI：
10.1176/appi.ajp.2009.09070931
发表时间：
2010-05
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Etkin A;Prater KE;Hoeft F;Menon V;Schatzberg AF
通讯作者：
Schatzberg AF