Histopathological and Immunohistochemical Features of Small to Big Satellite Nevus Uncover the Nevogenesis of Large/Giant Congenital Melanocytic Nevus.
Histopathological and Immunohistochemical Features of Small to Big Satellite Nevus Uncover the Nevogenesis of Large/Giant Congenital Melanocytic Nevus.
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小到大卫星痣的组织病理学和免疫组织化学特征揭示了大/巨大先天性黑素细胞痣的新生机制
DOI：
10.1155/2022/9024548
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发表时间：
2022
影响因子：
4.1
通讯作者：
Xie, Feng
中科院分区：
文献类型：
--
作者：
Gu, Jieyu;Wei, Boxuan;Gao, Bowen;Duan, Ran;Sheng, Lingling;Zheng, Danning;Bao, Yongyang;Xie, Feng
巨大/巨型先天性黑色素细胞痣(LgCMN)的发生是一个复杂的生物学过程，包括几个完整的产前阶段。由于伦理问题的限制，关于lgCMN是从表皮发育到真皮还是向相反方向发展的争论仍然存在争议。根据目前对伴随的卫星痣的研究，我们倾向于支持lgCMN从表皮发育到真皮。卫星痣分为3组：大(直径10 mm)、中(5 mm但≤10 mm)和小(≤5 mm)。采用苏木精-伊红染色和免疫组织化学方法(Sox10、Ki67、p16)比较不同类型卫星痣的细胞浸润深度和阳性染色情况。与大卫星痣相比，小卫星痣真皮中细胞浸润深度较小，真皮中表达Sox10和Ki67的细胞较多，表达p16的细胞较少。此外，从4例平均间隔1.75年连续切除lgCMN的患者中每例获得两个标本，以检查组织病理学变化。在本研究中，不同大小的卫星痣代表了lgCMN从早到晚的不同阶段，加深了我们对lgCMN新生的顺序阶段的理解。最初，异常的新生细胞沿着表皮播种、增殖和扩散。在从真皮内的乳头状真皮伸出的网脊上，一些巢细胞形成巢并逐渐渗入真皮。最终，新生细胞渗入真皮，进入内平衡状态。本研究为支持lgCMN中表皮到真皮新生的学说提供了新的证据。
The nevogenesis of large/giant congenital melanocytic nevus (lgCMN) is a complex biological process including several integral prenatal stages. Limited by ethical concerns, the debate of whether lgCMN develops from the epidermis to the dermis or in the opposite direction remains controversial. With the present study of the accompanying satellite nevi, we tend to support that lgCMN develops from epidermis to dermis. The satellite nevi were divided into 3 groups: big (diameter >10 mm), medium (>5 mm but ≤10 mm), and small (≤5 mm). Hematoxylin and eosin and immunohistochemical staining (SOX10, Ki67, and p16) were performed to compare the nevocyte infiltration depth as well as the positively stained rates among these satellite nevi. Compared to big satellite nevi, less deeply the nevocytes infiltrated the dermis, as well as more cells expressed SOX10 and Ki67 in the epidermis and fewer cells expressed p16 in the dermis of small satellite nevi. Additionally, two specimens were obtained from each of 4 patients who underwent serial resections of lgCMN at an average interval of 1.75 years to examine the histopathological changes. In the present study, satellite nevi of different sizes represent different stages of lgCMN from early to late, deepening our comprehension of the sequential stages of lgCMN nevogenesis. Initially, abnormal nevocytes seeded, proliferated, and spread along the epidermis. At rete ridges that protrude from the papillary dermis within the epidermis, some nevocytes formed nests and gradually penetrated into the dermis. Eventually, the nevocytes infiltrated the dermis and entered a homeostatic state. This study provides new evidence supporting the theory of epidermal-to-dermal nevogenesis in lgCMN.
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影响因子：
3.6
作者：
Grichnik, James M.;Ross, Andrew L.;Hatzistergos, Konstantinos E.
通讯作者：
Hatzistergos, Konstantinos E.
影响因子：
1.1
作者：
Kokta, Victor;Hung, Tawny;Barnhill, Raymond L.
通讯作者：
Barnhill, Raymond L.
DOI：
10.1097/pai.0000000000000428
发表时间：
2018-07-01
影响因子：
1.6
作者：
Uguen, Arnaud;Uguen, Marie;De Braekeleer, Marc
通讯作者：
De Braekeleer, Marc
影响因子：
6.5
作者：
Martins da Silva, Vanessa;Martinez-Barrios, Estefania;Malvehy, Josep
通讯作者：
Malvehy, Josep
影响因子：
8.8
作者：
Miller I;Min M;Yang C;Tian C;Gookin S;Carter D;Spencer SL
通讯作者：
Spencer SL