Cross-reactive antibody against human coronavirus OC43 spike protein correlates with disease severity in COVID-19 patients: a retrospective study.
Cross-reactive antibody against human coronavirus OC43 spike protein correlates with disease severity in COVID-19 patients: a retrospective study.
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DOI：
10.1080/22221751.2021.1905488
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发表时间：
2021-12
影响因子：
13.2
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Guo L;Wang Y;Kang L;Hu Y;Wang L;Zhong J;Chen H;Ren L;Gu X;Wang G;Wang C;Dong X;Wu C;Han L;Wang Y;Fan G;Zou X;Li H;Xu J;Jin Q;Cao B;Wang J
季节性人类冠状病毒（HCoV）包括HCoV-229 E、-OC 43、-NL 63和-HKU 1，在全球人群中广泛传播。然而，针对季节性HCoV的体液应答与COVID-19发病机制的相关性尚不清楚。在这项研究中，我们分析了从344名COVID-19患者中采集的838份血浆样本中SARS-CoV-2和季节性HCoV的S-IgG抗体的时间变化。我们检测了SARS-CoV-2和季节性HCoV之间S蛋白的抗原交叉反应性，并评估了COVID-19患者HCoV-OC 43 S-IgG水平与疾病严重程度之间的相关性。我们发现SARS-CoV-2 S-IgG滴度直到第22 - 28天才上升，而HCoV-OC 43抗体滴度直到第15 - 21天才上升，然后稳定到第46天。然而，针对HCoV-NL63、− 229E和-HKU1的IgG滴度没有显著增加。SARS-CoV-2和HCoV-OC 43之间存在双向交叉反应。在HCoV-OC 43 S-IgG阳性的健康对照中未检测到SARS-CoV-2中和抗体。HCoV-OC 43 S-IgG滴度在症状发作后第1 - 21天（PSO），重度疾病患者显著高于轻度患者。在需要机械通气的患者中也观察到较高水平的HCoV-OC 43 S-IgG。在第1 - 10天PSO，HCoV-OC 43 S-IgG滴度与60岁以上年龄组的疾病严重程度相关。我们的数据表明，在COVID-19患者中，针对HCoV-OC 43刺突蛋白的交叉反应性抗体与疾病严重程度之间存在相关性。
Seasonal human coronaviruses (HCoVs) including HCoV-229E, -OC43, -NL63, and -HKU1 widely spread in global human populations. However, the relevance of humoral response against seasonal HCoVs to COVID-19 pathogenesis is elusive. In this study, we profiled the temporal changes of IgG antibody against spike proteins (S-IgG) of SARS-CoV-2 and seasonal HCoVs in 838 plasma samples collected from 344 COVID-19 patients. We tested the antigenic cross-reactivities of S protein between SARS-CoV-2 and seasonal HCoVs and evaluated the correlations between the levels of HCoV-OC43 S-IgG and the disease severity in COVID-19 patients. We found that SARS-CoV-2 S-IgG titres mounted until days 22–28, whereas HCoV-OC43 antibody titres increased until days 15–21 and then plateaued until day 46. However, IgG titres against HCoV-NL63, −229E, and -HKU1 showed no significant increase. A two-way cross-reactivity was identified between SARS-CoV-2 and HCoV-OC43. Neutralizing antibodies against SARS-CoV-2 were not detectable in healthy controls who were positive for HCoV-OC43 S-IgG. HCoV-OC43 S-IgG titres were significantly higher in patients with severe disease than those in mild patients at days 1–21 post symptom onset (PSO). Higher levels of HCoV-OC43 S-IgG were also observed in patients requiring mechanical ventilation. At days 1–10 PSO, HCoV-OC43 S-IgG titres correlated to disease severity in the age group over 60. Our data indicate that there is a correlation between cross-reactive antibody against HCoV-OC43 spike protein and disease severity in COVID-19 patients.
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影响因子：
158.5
作者：
Li, Qun;Guan, Xuhua;Feng, Zijian
通讯作者：
Feng, Zijian
DOI：
10.15585/mmwr.mm6915e3
发表时间：
2020-04-17
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
Garg S;Kim L;Whitaker M;O'Halloran A;Cummings C;Holstein R;Prill M;Chai SJ;Kirley PD;Alden NB;Kawasaki B;Yousey-Hindes K;Niccolai L;Anderson EJ;Openo KP;Weigel A;Monroe ML;Ryan P;Henderson J;Kim S;Como-Sabetti K;Lynfield R;Sosin D;Torres S;Muse A;Bennett NM;Billing L;Sutton M;West N;Schaffner W;Talbot HK;Aquino C;George A;Budd A;Brammer L;Langley G;Hall AJ;Fry A
通讯作者：
Fry A
DOI：
10.1111/j.1469-0691.2009.02746.x
发表时间：
2009-12
期刊：
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
影响因子：
--
作者：
Ren L;Gonzalez R;Wang Z;Xiang Z;Wang Y;Zhou H;Li J;Xiao Y;Yang Q;Zhang J;Chen L;Wang W;Li Y;Li T;Meng X;Zhang Y;Vernet G;Paranhos-Baccalà G;Chen J;Jin Q;Wang J
通讯作者：
Wang J
影响因子：
82.9
作者：
Long, Quan-Xin;Liu, Bai-Zhong;Huang, Ai-Long
通讯作者：
Huang, Ai-Long
影响因子：
8.8
作者：
Chan, C. M.;Tse, Herman;Yuen, K. Y.
通讯作者：
Yuen, K. Y.