Prevalence of human respiratory viruses in adults with acute respiratory tract infections in Beijing, 2005-2007.
Prevalence of human respiratory viruses in adults with acute respiratory tract infections in Beijing, 2005-2007.
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DOI：
10.1111/j.1469-0691.2009.02746.x
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发表时间：
2009-12
期刊：
影响因子：
--
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Ren L;Gonzalez R;Wang Z;Xiang Z;Wang Y;Zhou H;Li J;Xiao Y;Yang Q;Zhang J;Chen L;Wang W;Li Y;Li T;Meng X;Zhang Y;Vernet G;Paranhos-Baccalà G;Chen J;Jin Q;Wang J
为了解成人急性呼吸道感染(ARTIS)常见呼吸道病毒的病原学作用和流行病学特征，于2005年5月至2007年7月在北京对中国进行了为期两年的研究。用聚合酶链式反应方法分析了5808例ARTI患者的鼻咽拭子标本中常见的呼吸道病毒，包括A、B和C的流感病毒(IFV)、1-4的副流感病毒(PIV)、肠道病毒(EV)、人鼻病毒(HRV)、呼吸道合胞病毒(RSV)、人类偏肺病毒(HMPV)、人类冠状病毒(HCoV)、OC43、229E、NL63和HKU1，以及腺病毒(ADV)。34.6%的患者样本中检测到病毒病原体，1.6%的患者对一种以上病毒检测呈阳性。检出病原体以IFV为主(19.3%)，其次为HRV(6.5%)、PIV(4.3%)、EVS(3.2%)和HCoV(1.1%)。ADV、RSV和HMPV也检出(1%)。在样本人群中，下呼吸道和上呼吸道感染的病毒检出率有显著差异：PIV是下急性呼吸道感染(LRTI)中第二常见的病毒病原体，高于上急性呼吸道感染，这表明PIV在LRTI中的致病作用值得研究。本研究是中国地区目前规模最大的呼吸道病毒感染多病原检测调查，为进一步研究成人ARTIS呼吸道病毒感染提供了基线数据。
To determine the aetiological role and epidemiological profile of common respiratory viruses in adults with acute respiratory tract infections (ARTIs), a 2‐year study was conducted in Beijing, China, from May 2005 to July 2007. Nose and throat swab samples from 5808 ARTI patients were analysed by PCR methods for common respiratory viruses, including influenza viruses (IFVs) A, B, and C, parainfluenza viruses (PIVs) 1–4, enteroviruses (EVs), human rhinoviruses (HRVs), respiratory syncytial virus (RSV), human metapneumovirus (HMPV), human coronaviruses (HCoVs) OC43, 229E, NL63, and HKU1, and adenoviruses (ADVs). Viral pathogens were detected in 34.6% of patient samples, and 1.6% of the patients tested positive for more than one virus. IFVs (19.3%) were the dominant agents detected, followed by HRVs (6.5%), PIVs (4.3%), EVs (3.2%), and HCoVs (1.1%). ADVs, RSV and HMPV were also detected (<1%). The viral detection rates differed significantly between infections of the lower and upper respiratory tracts in the sample population: PIVs, the second most commonly detected viral agents in lower acute respiratory tract infections (LRTIs), were more prevalent than in upper acute respiratory tract infections, indicating that the pathogenic role of PIVs in LRTIs should be investigated. Currently, this study is the largest‐scale investigation of respiratory virus infections in China with multiple agent detection, providing baseline data for further studies of respiratory virus infections in adults with ARTIs.
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DOI：
10.1111/j.1469-0691.2006.01506.x
发表时间：
2006-11
期刊：
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
影响因子：
--
作者：
Koetz A;Nilsson P;Lindén M;van der Hoek L;Ripa T
通讯作者：
Ripa T
影响因子：
12.7
作者：
Pierangeli, Alessandra;Gentile, Massimo;Antonelli, Guido
通讯作者：
Antonelli, Guido
DOI：
10.1073/pnas.0504666102
发表时间：
2005-09-06
影响因子：
11.1
作者：
Allander, T;Tammi, MT;Andersson, B
通讯作者：
Andersson, B
影响因子：
12.7
作者：
Coiras, MT;Aguilar, JC;Pérez-Breña, P
通讯作者：
Pérez-Breña, P
影响因子：
4.2
作者：
Kaye, M.;Skidmore, S.;Warren, R.
通讯作者：
Warren, R.