A Glycolipid α-GalCer Derivative, 7DW8-5 as a Novel Mucosal Adjuvant for the Split Inactivated Influenza Vaccine.
A Glycolipid α-GalCer Derivative, 7DW8-5 as a Novel Mucosal Adjuvant for the Split Inactivated Influenza Vaccine.
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DOI：
10.3390/v14061174
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发表时间：
2022-05-28
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影响因子：
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流感病毒感染宿主并通过呼吸道传播（即，口和鼻）;因此，与有效的粘膜佐剂结合的模拟自然感染的鼻内流感疫苗的开发是当前肠胃外疫苗的有吸引力的替代方案。然而，随着霍乱毒素和大肠杆菌不耐热内毒素由于副作用而退出临床使用，没有批准的用于鼻内疫苗的佐剂。因此，迫切需要安全有效的粘膜佐剂。我们曾报道过α-半乳糖神经酰胺（α-GalCer）的衍生物7 DW 8 -5可增强流感裂解疫苗的免疫保护效果。然而，7 DW 8 -5的粘膜佐剂性仍不清楚。在本研究中，我们发现7 DW 8 -5促进分泌伊加抗体和IgG抗体的产生，并通过鼻内给药增强流感裂解疫苗的保护效力。此外，7 DW 8 -5与裂解流感疫苗的共同施用显著减少了致死攻击后上呼吸道和下呼吸道中的病毒脱落。我们的研究结果表明，7 DW 8 -5是一种新的粘膜佐剂裂解流感疫苗。
Influenza virus infects the host and transmits through the respiratory tract (i.e., the mouth and nose); therefore, the development of intranasal influenza vaccines that mimic the natural infection, coupled with an efficient mucosal adjuvant, is an attractive alternative to current parenteral vaccines. However, with the withdrawal of cholera toxin and Escherichia coli heat-labile endotoxin from clinical use due to side effects, there are no approved adjuvants for intranasal vaccines. Therefore, safe and effective mucosal adjuvants are urgently needed. Previously, we reported that one derivative of α-Galactosylceramide (α-GalCer), 7DW8-5, could enhance the protective efficacy of split influenza vaccine by injection administration. However, the mucosal adjuvanticity of 7DW8-5 is still unclear. In this study, we found that 7DW8-5 promotes the production of secret IgA antibodies and IgG antibodies and enhances the protective efficacy of the split influenza vaccine by intranasal administration. Furthermore, co-administration of 7DW8-5 with the split influenza vaccine significantly reduces the virus shedding in the upper and lower respiratory tract after lethal challenge. Our results demonstrate that 7DW8-5 is a novel mucosal adjuvant for the split influenza vaccine.
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影响因子：
5.5
作者：
Uraki R;Das SC;Hatta M;Kiso M;Iwatsuki-Horimoto K;Ozawa M;Coban C;Ishii KJ;Kawaoka Y
通讯作者：
Kawaoka Y
DOI：
10.1128/aem.16.4.588-594.1968
发表时间：
1968-01-01
期刊：
APPLIED MICROBIOLOGY
影响因子：
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作者：
GAUSH, CR;SMITH, TF
通讯作者：
SMITH, TF
作为自我辅助癌症疫苗的 Tn-RC-529 衍生物缀合物的全合成和生物活性评估
DOI：
10.1038/s41570-020-00244-3
发表时间：
2021
期刊：
Nature reviews. Chemistry
影响因子：
--
作者：
Pifferi C;Fuentes R;Fernández-Tejada A
通讯作者：
Fernández-Tejada A
影响因子：
6.4
作者：
Ichinohe, Takeshi;Tamura, Shin-ichi;Hasegawa, Hideki
通讯作者：
Hasegawa, Hideki
影响因子：
--
作者：
Han SK;Lee D;Lee H;Kim D;Son HG;Yang JS;Lee SV;Kim S
通讯作者：
Kim S