The mechanical role of the cervix in pregnancy.
The mechanical role of the cervix in pregnancy.
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DOI：
10.1016/j.jbiomech.2015.02.065
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发表时间：
2015-06-25
影响因子：
2.4
通讯作者：
House, Michael
中科院分区：
文献类型：
--
作者：
Myers, Kristin M.;Feltovich, Helen;Mazza, Edoardo;Vink, Joy;Bajka, Michael;Wapner, Ronald J.;Hall, Timothy J.;House, Michael
适当的子宫颈机械功能对维持妊娠至足月，使胎儿能够充分发育至关重要。然而，在怀孕结束时，子宫颈必须允许分娩，这就要求它明显变软、变短和扩张。自然早产是全球5岁以下儿童死亡的主要原因，有多种途径导致自然早产，但最终都导致宫颈过早改变，因为这是最终常见分娩途径的最后一步。妊娠期宫颈过早改变的机制尚不清楚，因此目前评估早产风险的临床方案仅限于机械功能的替代标志物，如超声测量的宫颈长度。这就是我们研究子宫颈的动机，为此，我们建议在研究子宫颈临床功能的同时，对其结构功能进行定量工程评估。我们渴望开发一种通用的翻译语言，并产生一个严格的综合临床工程框架，用于评估细胞到器官水平的颈椎机械功能。在这篇综述中，我们通过描述与妊娠期间子宫颈机械功能相关的临床、生化和工程概念的当前景观，着手解决这一挑战。我们的目标是利用这个共同的平台来激发新的方法来描述正常和异常的妊娠期宫颈功能。
Appropriate mechanical function of the uterine cervix is critical for maintaining a pregnancy to term so that the fetus can develop fully. At the end of pregnancy, however, the cervix must allow delivery, which requires it to markedly soften, shorten and dilate. There are multiple pathways to spontaneous preterm birth, the leading global cause of death in children less than 5 years old, but all culminate in premature cervical change, because that is the last step in the final common pathway to delivery. The mechanisms underlying premature cervical change in pregnancy are poorly understood, and therefore current clinical protocols to assess preterm birth risk are limited to surrogate markers of mechanical function, such as sonographically measured cervical length. This is what motivates us to study the cervix, for which we propose investigating clinical cervical function in parallel with a quantitative engineering evaluation of its structural function. We aspire to develop a common translational language, as well as generate a rigorous integrated clinical-engineering framework for assessing cervical mechanical function at the cellular to organ level. In this review, we embark on that challenge by describing the current landscape of clinical, biochemical, and engineering concepts associated with the mechanical function of the cervix during pregnancy. Our goal is to use this common platform to inspire novel approaches to delineation of normal and abnormal cervical function in pregnancy.
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影响因子：
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