Altered Brain Functional Hubs and Connectivity in Type 2 Diabetes Mellitus Patients: A Resting-State fMRI Study.
Altered Brain Functional Hubs and Connectivity in Type 2 Diabetes Mellitus Patients: A Resting-State fMRI Study.
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2 型糖尿病患者大脑功能中枢和连接性的改变：静息态 fMRI 研究。
DOI：
10.3389/fnagi.2018.00055
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发表时间：
2018
影响因子：
4.8
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Liu D;Duan S;Zhou C;Wei P;Chen L;Yin X;Zhang J;Wang J
2型糖尿病（T2DM）影响广大人群，并与认知障碍密切相关。然而，T2DM患者认知功能障碍的机制尚未阐明。在神经影像学的基础上研究脑功能网络的基本单元（节点或枢纽和边缘），有助于我们进一步了解T2DM患者脑功能网络的变化模式。本研究采用度中心性分析方法研究了脑功能枢纽的变化模式，并采用功能连通性和格兰杰因果关系分析方法研究了脑功能枢纽之间的连通性。与健康对照组相比，T2DM患者左侧扣带回前部（ACG）DC值较高，双侧枕叶外侧皮质（OCL）和右侧中央前回（PreCG）DC值较低。2型糖尿病患者左前扣带回与右前扣带回之间的功能连接较强，而右前扣带回与双侧前扣带回之间的功能连接较弱。在T2DM患者中观察到左侧ACG对左侧ACG的负因果效应和左侧ACG对右侧ACG的正因果效应，而在健康对照组中则相反。此外，T2DM患者的正常脑功能储备与血糖参数升高呈负相关。这项研究表明，有脑功能枢纽和连接的改变，可能反映了异常的信息沟通，在T2DM患者的大脑。这一发现可能有助于我们进一步了解T2DM相关认知功能障碍的机制。
Type 2 diabetes mellitus (T2DM) affects a vast population and is closely associated with cognitive impairment. However, the mechanisms of cognitive impairment in T2DM patients have not been unraveled. Research on the basic units (nodes or hubs and edges) of the brain functional network on the basis of neuroimaging may advance our understanding of the network change pattern in T2DM patients. This study investigated the change patterns of brain functional hubs using degree centrality (DC) analysis and the connectivity among these hubs using functional connectivity and Granger causality analysis. Compared to healthy controls, the DC values were higher in the left anterior cingulate gyrus (ACG) and lower in the bilateral lateral occipital cortices (LOC) and right precentral gyrus (PreCG) in T2DM patients. The functional connectivity between the left ACG and the right PreCG was stronger in T2DM patients, whereas the functional connectivity among the right PreCG and bilateral LOC was weaker. A negative causal effect from the left ACG to left LOC and a positive effect from the left ACG to right LOC were observed in T2DM patients, while in healthy controls, the opposite occurred. Additionally, the reserve of normal brain function in T2DM patients was negatively associated with the elevated glycemic parameters. This study demonstrates that there are brain functional hubs and connectivity alterations that may reflect the aberrant information communication in the brain of T2DM patients. The findings may advance our understanding of the mechanisms of T2DM-related cognitive impairment.
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