Adhesive mechanisms governing interferon-producing cell recruitment into lymph nodes.
Adhesive mechanisms governing interferon-producing cell recruitment into lymph nodes.
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DOI：
10.1084/jem.20051035
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发表时间：
2005-09-05
期刊：
影响因子：
--
通讯作者：
Colonna M
中科院分区：
文献类型：
--
作者：
Diacovo TG;Blasius AL;Mak TW;Cella M;Colonna M
天然干扰素产生细胞（IPCs）存在于外周淋巴结（pln）中，它们支持NK细胞、T细胞和B细胞对病原体的反应。然而，它们的进入途径和粘附机制仍然不明确。我们报道IPCs可以通过血液途径进入pln，这涉及一个多步骤的粘附过程，并且炎症会增强转运。结果表明，在非刺激和炎症的pln中，IPCs上的l -选择素对于体内高内皮小静脉的有效附着和滚动是必需的。然而，IPCs也具有e -选择素的功能配体，仅在后一种情况下有助于这一过程。结合选择素介导的粘附，β 1-和β 2-整合素都参与IPC对炎症血管壁的附着，而趋化性部分依赖于趋化因子受体CCR5。确定IPC转运到pln所需的粘附机制可能为调节依赖于这些细胞活性的免疫反应提供机会。
Natural interferon-producing cells (IPCs) are found in peripheral lymph nodes (PLNs), where they support NK cell, T cell, and B cell responses to pathogens. However, their route of entry and the adhesive mechanisms used to gain access to PLNs remain poorly defined. We report that IPCs can enter PLNs via a hematogenous route, which involves a multistep adhesive process, and that transmigration is enhanced by inflammation. Results indicate that L-selectin on IPCs is required for efficient attachment and rolling on high endothelial venules in vivo in both nonstimulated and inflamed PLNs. IPCs, however, also possess functional ligands for E-selectin that contribute to this process only in the latter case. In conjunction with selectin-mediated adhesion, both β 1- and β 2-integrins participate in IPC attachment to the inflamed vessel wall, whereas chemotaxis relies in part on the chemokine receptor CCR5. Identification of the adhesive machinery required for IPC trafficking into PLNs may provide opportunities to regulate immune responses reliant on the activity of these cells.
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DOI：
10.1084/jem.20020045
发表时间：
2002-04-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Gilliet M;Boonstra A;Paturel C;Antonenko S;Xu XL;Trinchieri G;O'Garra A;Liu YJ
通讯作者：
Liu YJ
影响因子：
30.5
作者：
Cella, M;Facchetti, F;Colonna, M
通讯作者：
Colonna, M
影响因子：
20.3
作者：
Blasius, A;Vermi, W;Colonna, M
通讯作者：
Colonna, M
影响因子：
4.4
作者：
Asselin-Paturel, C;Brizard, G;Trinchieri, G
通讯作者：
Trinchieri, G
DOI：
10.1084/jem.192.10.1515
发表时间：
2000-11-20
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Hancock WW;Lu B;Gao W;Csizmadia V;Faia K;King JA;Smiley ST;Ling M;Gerard NP;Gerard C
通讯作者：
Gerard C