Slow-wave sleep is controlled by a subset of nucleus accumbens core neurons in mice.
Slow-wave sleep is controlled by a subset of nucleus accumbens core neurons in mice.
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慢波睡眠由小鼠伏隔核核心神经元的子集控制
DOI：
10.1038/s41467-017-00781-4
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发表时间：
2017-09-29
影响因子：
16.6
通讯作者：
Lazarus M
中科院分区：
文献类型：
--
作者：
Oishi Y;Xu Q;Wang L;Zhang BJ;Takahashi K;Takata Y;Luo YJ;Cherasse Y;Schiffmann SN;de Kerchove d'Exaerde A;Urade Y;Qu WM;Huang ZL;Lazarus M
睡眠控制被归因于两个过程模型，这是一个被广泛接受的概念，假定稳态驱动和昼夜节律过程是主要的睡眠调节因素。认知和情绪因素也会影响睡眠-觉醒行为;然而，它们对睡眠控制的影响背后的精确电路机制尚不清楚。以前的研究表明，腺苷在影响行为唤醒的神经核（NAc）中发挥作用，这是一个对强化和奖励至关重要的大脑区域。在这里，我们表明，化学或光遗传激活兴奋性腺苷A2 A受体表达的间接通路神经元的核心区域的NAC强烈诱导慢波睡眠。化学发生抑制NAc间接通路神经元阻止睡眠诱导，但不影响稳态睡眠反弹。此外，动机刺激抑制腹侧苍白球投射NAc间接通路神经元的活动并抑制睡眠。我们的研究结果揭示了这一间接途径对睡眠控制与动机相关的突出贡献。除了昼夜节律和稳态驱动外，动机水平也会影响睡眠-觉醒周期。在这里，作者证明，腺苷受体表达神经元在丘脑核的核心项目腹侧苍白球被抑制的动机刺激和因果关系参与控制慢波睡眠。
Sleep control is ascribed to a two-process model, a widely accepted concept that posits homoeostatic drive and a circadian process as the major sleep-regulating factors. Cognitive and emotional factors also influence sleep–wake behaviour; however, the precise circuit mechanisms underlying their effects on sleep control are unknown. Previous studies suggest that adenosine has a role affecting behavioural arousal in the nucleus accumbens (NAc), a brain area critical for reinforcement and reward. Here, we show that chemogenetic or optogenetic activation of excitatory adenosine A2A receptor-expressing indirect pathway neurons in the core region of the NAc strongly induces slow-wave sleep. Chemogenetic inhibition of the NAc indirect pathway neurons prevents the sleep induction, but does not affect the homoeostatic sleep rebound. In addition, motivational stimuli inhibit the activity of ventral pallidum-projecting NAc indirect pathway neurons and suppress sleep. Our findings reveal a prominent contribution of this indirect pathway to sleep control associated with motivation. In addition to circadian and homoeostatic drives, motivational levels influence sleep−wake cycles. Here the authors demonstrate that adenosine receptor-expressing neurons in the nucleus accumbens core that project to the ventral pallidum are inhibited by motivational stimuli and are causally involved in the control of slow-wave sleep.
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影响因子：
16.6
作者：
Anaclet C;Pedersen NP;Ferrari LL;Venner A;Bass CE;Arrigoni E;Fuller PM
通讯作者：
Fuller PM
影响因子：
25
作者：
Eban-Rothschild A;Rothschild G;Giardino WJ;Jones JR;de Lecea L
通讯作者：
de Lecea L
影响因子：
56.9
作者：
Porkka-Heiskanen, T;Strecker, RE;McCarley, RW
通讯作者：
McCarley, RW
影响因子：
4.4
作者：
Fernandez-Mendoza, Julio;Shaffer, Michele L.;Vela-Bueno, Antonio
通讯作者：
Vela-Bueno, Antonio
影响因子：
1.2
作者：
Oishi, Yo;Takata, Yohko;Lazarus, Michael
通讯作者：
Lazarus, Michael