Reproducibility assessment of brain responses to visual food stimuli in adults with overweight and obesity.
Reproducibility assessment of brain responses to visual food stimuli in adults with overweight and obesity.
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DOI：
10.1002/oby.21603
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发表时间：
2016-10
期刊：
影响因子：
6.9
通讯作者：
Campbell, Wayne W.
中科院分区：
文献类型：
--
作者：
Sayer, R. Drew;Tamer, Gregory G., Jr.;Chen, Ningning;Tregellas, Jason R.;Cornier, Marc-Andre;Kareken, David A.;Talavage, Thomas M.;McCrory, Megan A.;Campbell, Wayne W.
大脑的奖励系统影响摄食行为，从而影响肥胖风险。功能磁共振成像（fMRI）是研究大脑奖赏功能的常用方法。我们试图使用BOLD功能磁共振成像来评估禁食状态下大脑对视觉食物刺激的反应的可重复性。先验的大脑区域的利益，包括双边杏仁核，眶额皮质，尾状核，壳核。28名超重或肥胖的女性（n=16）和男性（n=12）在2天内完成了空腹状态fMRI和食欲评估。通过比较平均禁食状态脑反应和测量2个测试日这些反应的重测信度来评估生殖能力。与第1天相比，第2天左杏仁核和右杏仁核的平均禁食状态脑反应降低，但其他感兴趣区域的平均第1天和第2天反应无差异。除了左眶额皮质反应（一般的可靠性），大脑反应的重测可靠性差或不可靠。fMRI测量的超重或肥胖成年人对视觉食物线索的反应显示出相对较好的平均水平再现性，但受试者内变异性相当大。差的重测信度降低了观察到真实相关性的可能性，并增加了研究所需的样本量。
The brain’s reward system influences ingestive behavior and subsequently, obesity risk. Functional magnetic resonance imaging (fMRI) is a common method for investigating brain reward function. We sought to assess the reproducibility of fasting-state brain responses to visual food stimuli using BOLD fMRI. A priori brain regions of interest included bilateral insula, amygdala, orbitofrontal cortex, caudate, and putamen. Fasting-state fMRI and appetite assessments were completed by 28 women (n=16) and men (n=12) with overweight or obesity on 2 days. Reproducibility was assessed by comparing mean fasting-state brain responses and measuring test-retest reliability of these responses on the 2 testing days. Mean fasting-state brain responses on Day 2 were reduced compared to Day 1 in the left insula and right amygdala, but mean Day 1 and Day 2 responses were not different in the other regions of interest. With the exception of the left orbitofrontal cortex response (fair reliability), test-retest reliabilities of brain responses were poor or unreliable. fMRI-measured responses to visual food cues in adults with overweight or obesity show relatively good mean-level reproducibility, but considerable within-subject variability. Poor test-retest reliability reduces the likelihood of observing true correlations and increases the necessary sample sizes for studies.
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影响因子：
3.5
作者：
Peirce, Jonathan W.
通讯作者：
Peirce, Jonathan W.
DOI：
10.1186/1479-5868-8-101
发表时间：
2011-09-25
影响因子：
8.7
作者：
Burger, Kyle S.;Cornier, Marc A.;Johnson, Susan L.
通讯作者：
Johnson, Susan L.
影响因子：
7.1
作者：
Cornier, Marc-Andre;Von Kaenel, Sandra S.;Tregellas, Jason R.
通讯作者：
Tregellas, Jason R.
影响因子：
2.9
作者：
Cornier, Marc-Andre
通讯作者：
Cornier, Marc-Andre
影响因子：
2
作者：
MULLER, R;BUTTNER, P
通讯作者：
BUTTNER, P