Dopamine regulation of social choice in a monogamous rodent species.

Dopamine regulation of social choice in a monogamous rodent species.
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DOI:
10.3389/neuro.08.015.2009
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发表时间:
2009
影响因子:
3
通讯作者:
Wang Z
Wang Z
中科院分区:
医学3区
文献类型:
--
作者:
Aragona BJ;Wang Z

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人们越来越认识到,人类的社会决策受到享乐和情感处理的强烈影响。社会神经经济学领域表明,对奖励很重要的神经系统与人类的社会选择和社会偏好相关。在这里,我们表明,一夫一妻制的啮齿动物(草原田鼠)的社会偏好的神经生物学也受到参与奖励和情绪处理的神经系统的调节。具体来说,我们描述了中脑边缘多巴胺传递如何差异介导该物种一夫一妻制配对键的形成和维持。因此,奖励处理对社会选择行为发挥着巨大的调节作用,而社会选择行为是相当复杂的社会组织的基础。我们的结论是,草原田鼠是社会选择神经科学的一个优秀模型系统,复杂的社会决策可以通过奖励和享乐处理来强有力地解释。
There is growing appreciation that social decision making in humans is strongly influenced by hedonic and emotional processing. The field of social neuroeconomics has shown that neural systems important for reward are associated with social choice and social preferences in humans. Here, we show that the neurobiology of social preferences in a monogamous rodent species, the prairie vole, is also regulated by neural systems involved in reward and emotional processing. Specifically, we describe how mesolimbic dopamine transmission differentially mediates the formation and maintenance of monogamous pair bonds in this species. Thus, reward processing exerts tremendous regulation over social choice behaviors that serve as the foundation of a rather complex social organization. We conclude that prairie voles are an excellent model system for the neuroscience of social choice and that complex social decision-making can be robustly explained by reward and hedonic processing.
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