A mesocortical glutamatergic pathway modulates neuropathic pain independent of dopamine co-release.
A mesocortical glutamatergic pathway modulates neuropathic pain independent of dopamine co-release.
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一种不依赖于多巴胺共同释放的中皮层神经递质能通路调节神经病理性疼痛。
DOI：
10.1038/s41467-024-45035-2
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发表时间：
2024-01-20
影响因子：
16.6
通讯作者：
Yang, Guang
中科院分区：
文献类型：
--
作者：
Li, Miao;Yang, Guang
Dysfunction in the mesocortical pathway, connecting the ventral tegmental area (VTA) to the prefrontal cortex, has been implicated in chronic pain. While extensive research has focused on the role of dopamine, the contribution of glutamatergic signaling in pain modulation remains unknown. Using in vivo calcium imaging, we observe diminished VTA glutamatergic activity targeting the prelimbic cortex (PL) in a mouse model of neuropathic pain. Optogenetic activation of VTA glutamatergic terminals in the PL alleviates neuropathic pain, whereas inhibiting these terminals in naïve mice induces pain-like responses. Importantly, this pain-modulating effect is independent of dopamine co-release, as demonstrated by CRISPR/Cas9-mediated gene deletion. Furthermore, we show that VTA neurons primarily project to excitatory neurons in the PL, and their activation restores PL outputs to the anterior cingulate cortex, a key region involved in pain processing. These findings reveal a distinct mesocortical glutamatergic pathway that critically modulates neuropathic pain independent of dopamine signaling. The role of mesocortical pathway in pain modulation is poorly understood. Here, authors show in mice that enhancing ventral tegmental area to prefrontal cortex glutamatergic activity alleviates neuropathic pain independently of dopamine co-release.
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影响因子：
4.7
作者：
Li M;Cabrera-Garcia D;Salling MC;Au E;Yang G;Harrison NL
通讯作者：
Harrison NL
影响因子：
18.2
作者：
Hnasko TS;Edwards RH
通讯作者：
Edwards RH
影响因子：
2.5
作者：
Ji, Guangchen;Neugebauer, Volker
通讯作者：
Neugebauer, Volker
DOI：
10.1073/pnas.0910986107
发表时间：
2010-01-05
影响因子：
11.1
作者：
Birgner, Carolina;Nordenankar, Karin;Wallen-Mackenzie, Asa
通讯作者：
Wallen-Mackenzie, Asa
影响因子：
3
作者：
Cichon, Joseph;Magrane, Jordi;Gan, Wen-Biao
通讯作者：
Gan, Wen-Biao