Alcohol reduces the activity of somatostatin interneurons in the mouse prefrontal cortex: A neural basis for its disinhibitory effect?
Alcohol reduces the activity of somatostatin interneurons in the mouse prefrontal cortex: A neural basis for its disinhibitory effect?
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DOI：
10.1016/j.neuropharm.2021.108501
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发表时间：
2021-05-01
影响因子：
4.7
通讯作者：
Harrison NL
中科院分区：
文献类型：
--
作者：
Li M;Cabrera-Garcia D;Salling MC;Au E;Yang G;Harrison NL
前额叶皮层（PFC）参与行为的执行（“自上而下”）控制，其功能特别容易受到酒精的影响，导致与决策，反应抑制，社交焦虑和工作记忆改变相关的行为去抑制。PFC的回路涉及锥体神经元（PNs）和抑制性中间神经元（INs）的几个亚类之间复杂的相互作用，包括生长抑素（SST）表达的INs。引起SST INs的中度激活和PNs的弱抑制。在中等至高剂量下，酒精（2-3 g/kg）强烈抑制SST INs在体内的活性，这种作用可能导致抑制解除，因为PN亚群的活性同时增强。相反，使用离体电生理学在脑切片中的记录显示，在与体内实验中达到的血液酒精水平一致的浓度范围（20和50 mM）内，酒精对SST IN或PN的兴奋性没有直接影响。酒精对体内SST INs的这种剂量依赖性作用可能揭示了酒精在PFC中由PFC回路内部或外部的其他神经元介导的去抑制作用的神经基础。
The prefrontal cortex (PFC) is involved in executive (“top-down”) control of behavior and its function is especially susceptible to the effects of alcohol, leading to behavioral disinhibition that is associated with alterations in decision making, response inhibition, social anxiety and working memory. The circuitry of the PFC involves a complex interplay between pyramidal neurons (PNs) and several subclasses of inhibitory interneurons (INs), including somatostatin (SST)-expressing INs. Using in vivo calcium imaging, we showed that alcohol dose-dependently altered network activity in layers 2/3 of the prelimbic subregion of the mouse PFC. Low doses of alcohol (1 g/kg, intraperitoneal, i.p.) caused moderate activation of SST INs and weak inhibition of PNs. At moderate to high doses, alcohol (2–3 g/kg) strongly inhibited the activity of SST INs in vivo, and this effect may result in disinhibition, as the activity of a subpopulation of PNs was simultaneously enhanced. In contrast, recordings in brain slices using ex vivo electrophysiology revealed no direct effect of alcohol on the excitability of either SST INs or PNs over a range of concentrations (20 and 50 mM) consistent with the blood alcohol levels reached in the in vivo experiments. This dose-dependent effect of alcohol on SST INs in vivo may reveal a neural basis for the disinhibitory effect of alcohol in the PFC mediated by other neurons within or external to the PFC circuitry.
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影响因子：
--
作者：
Canetta S;Teboul E;Holt E;Bolkan SS;Padilla-Coreano N;Gordon JA;Harrison NL;Kellendonk C
通讯作者：
Kellendonk C
小鼠外部苍白球中的乙醇敏感起搏器神经元。
DOI：
10.1038/npp.2016.251
发表时间：
2017-04
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
Abrahao KP;Chancey JH;Chan CS;Lovinger DM
通讯作者：
Lovinger DM
影响因子：
16.2
作者：
Fino E;Yuste R
通讯作者：
Yuste R
DOI：
10.1523/jneurosci.0895-11.2011
发表时间：
2011-07-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Ballard IC;Murty VP;Carter RM;MacInnes JJ;Huettel SA;Adcock RA
通讯作者：
Adcock RA
影响因子：
3
作者：
Cichon, Joseph;Magrane, Jordi;Gan, Wen-Biao
通讯作者：
Gan, Wen-Biao