Alcohol and tobacco lower the age of presentation in sporadic pancreatic cancer in a dose-dependent manner: a multicenter study.
Alcohol and tobacco lower the age of presentation in sporadic pancreatic cancer in a dose-dependent manner: a multicenter study.
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DOI：
10.1038/ajg.2012.288
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发表时间：
2012-11
影响因子：
9.8
通讯作者：
Brand, Randall E.
中科院分区：
文献类型：
--
作者：
Anderson, Michelle A.;Zolotarevsky, Eugene;Cooper, Kristine L.;Sherman, Simon;Shats, Oleg;Whitcomb, David C.;Lynch, Henry T.;Ghiorzo, Paola;Rubinstein, Wendy S.;Vogel, Kristen J.;Sasson, Aaron R.;Grizzle, William E.;Ketcham, Marsha A.;Lee, Shih-Yuan;Normolle, Daniel;Plonka, Caitlyn M.;Mertens, Amy N.;Tripon, Renee C.;Brand, Randall E.
本研究的目的是研究烟草和酒精剂量和类型与胰腺癌（PancCa）发病年龄之间的关系。来自胰腺癌协作登记处的前瞻性数据用于检查发病年龄与感兴趣的变量之间的关联，这些变量包括：性别，种族，出生国家，教育状况，PancCa家族史，糖尿病状态以及烟草和酒精使用。统计分析包括逻辑和线性回归、考克斯比例风险回归和至事件发生时间分析。PancCa的中位诊断年龄为66.3岁（95%置信区间（CI）为64.5-68.0）。男性比女性更可能是吸烟者（77%比69%，P = 0.0002）和重度酒精和啤酒消费者（19%比6%，34%比19%，P < 0.0001）。在对PancCa表现年龄影响的单变量分析中，以下因素具有显著性：性别、酒精和烟草使用（数量、状态和类型）、PancCa家族史和体重指数。酒精和烟草都有剂量依赖性效应。在多变量分析中，酒精状态和剂量与早期PancCa发作的风险增加独立相关，重度饮酒者的风险最大（HR 1.62，95%CI 1.04-2.54）。吸烟状态对早发性胰腺癌的风险最高，活跃吸烟者的HR为2.69（95% CI，1.97-3.68），剂量具有独立效应（P = 0.019）。酒精和烟草的有害影响似乎在禁欲10年后消失。酒精和烟草的使用与PancCa发病年龄较早的剂量相关风险增加有关。虽然喝啤酒的人比不喝啤酒的人患胰腺癌的年龄要早，但在控制了酒精剂量后，酒精类型并没有显着的影响。
The objective of this study was to examine the association between tobacco and alcohol dose and type and the age of onset of pancreatic adenocarcinoma (PancCa). Prospective data from the Pancreatic Cancer Collaborative Registry were used to examine the association between age of onset and variables of interest including: gender, race, birth country, educational status, family history of PancCa, diabetes status, and tobacco and alcohol use. Statistical analysis included logistic and linear regression, Cox proportional hazard regression, and time-to-event analysis. The median age to diagnosis for PancCa was 66.3 years (95% confidence intervals (CIs), 64.5–68.0). Males were more likely than females to be smokers (77% vs. 69%, P = 0.0002) and heavy alcohol and beer consumers (19% vs. 6%, 34% vs. 19%, P < 0.0001). In univariate analysis for effects on PancCa presentation age, the following were significant: gender, alcohol and tobacco use (amount, status and type), family history of PancCa, and body mass index. Both alcohol and tobacco had dose-dependent effects. In multivariate analysis, alcohol status and dose were independently associated with increased risk for earlier PancCa onset with greatest risk occurring in heavy drinkers (HR 1.62, 95% CI 1.04–2.54). Smoking status had the highest risk for earlier onset pancreatic cancer with a HR of 2.69 (95% CI, 1.97–3.68) for active smokers and independent effects for dose (P = 0.019). The deleterious effects for alcohol and tobacco appear to resolve after 10 years of abstinence. Alcohol and tobacco use are associated with a dose-related increased risk for earlier age of onset of PancCa. Although beer drinkers develop pancreatic cancer at an earlier age than nondrinkers, alcohol type did not have a significant effect after controlling for alcohol dose.
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影响因子：
3
作者：
Acott, Alison A.;Theus, Sue A.;Mancino, Anne T.
通讯作者：
Mancino, Anne T.
影响因子：
9.8
作者：
Poley, J. W.;Kluijt, I.;Bruno, M. J.
通讯作者：
Bruno, M. J.
影响因子：
6.2
作者：
James, TA;Sheldon, DG;Gibbs, JF
通讯作者：
Gibbs, JF
影响因子：
2.3
作者：
Gupta, Samir;Wang, Furong;Holly, Elizabeth A.;Bracci, Paige M.
通讯作者：
Bracci, Paige M.
DOI：
10.1007/s00432-007-0332-8
发表时间：
2008-07-01
影响因子：
3.6
作者：
Peppone, Luke J.;Mahoney, Martin C.;Hyland, Andrew
通讯作者：
Hyland, Andrew