Risk of pancreatic cancer by alcohol dose, duration, and pattern of consumption, including binge drinking: a population-based study.
Risk of pancreatic cancer by alcohol dose, duration, and pattern of consumption, including binge drinking: a population-based study.
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DOI：
10.1007/s10552-010-9533-6
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发表时间：
2010-07
影响因子：
2.3
通讯作者：
Bracci, Paige M.
中科院分区：
文献类型：
--
作者：
Gupta, Samir;Wang, Furong;Holly, Elizabeth A.;Bracci, Paige M.
关键词：
饮酒被认为是胰腺癌（PCA）的一个危险因素，但缺乏与消费特征相关的风险程度的澄清。我们在旧金山弗朗西斯科海湾地区进行了一项基于人群的病例对照研究（532例，1,701例对照），研究了饮酒与PCA之间的关系。以人群为基础的控制频率匹配的性别，年龄在5年内的类别和县的居住情况下，确定了癌症登记的快速病例确定。在面对面访谈期间收集了详细的饮酒数据，包括酗酒（≥5杯/天）。采用校正的非条件logistic回归计算比值比（OR）和95%置信区间（95%CI）。根据剂量，持续时间和饮酒模式，男性的OR增加了1.5至6倍，但女性没有。在男性中，OR随着总体饮酒量的增加而增加（22-35杯/周OR = 2.2，95% CI = 1.1-4.0; ≥35杯/周OR = 2.6，95% CI = 1.3-5.1，p趋势= 0.04）。最显著的影响是有酗酒史（OR = 3.5，95% CI = 1.6-7.5），包括每天饮酒次数增加（p趋势= 0.002）和酗酒年数增加（p趋势= 0.0006）。在包括吸烟和其他混杂因素的完全校正模型中，男性酗酒的OR略高于年龄校正模型。我们详细分析的结果支持重度饮酒（包括酗酒）是男性PCA的风险因素。
Alcohol consumption is postulated to be a risk factor for pancreatic cancer (PCA), but clarification of degree of risk related to consumption characteristics is lacking. We examined the association between alcohol consumption and PCA in a population-based case–control study (532 cases, 1,701 controls) in the San Francisco Bay Area. Population-based controls were frequency-matched by sex, age within 5-year categories and county of residence to cases identified by the cancer registry’s rapid case ascertainment. Detailed alcohol consumption data, including binge drinking (≥5 drinks/day), were collected during in-person interviews. Odds ratios (OR) and 95% confidence intervals (95% CI) were computed using adjusted unconditional logistic regression. Depending on dose, duration, and pattern of drinking, ORs were increased 1.5- to 6-fold among men but not women. In men, ORs increased with increasing overall alcohol consumption (22–35 drinks/week OR = 2.2, 95% CI = 1.1–4.0; ≥35 drinks/week OR = 2.6, 95% CI = 1.3–5.1, p-trend = 0.04). Most notable were effects with a history of binge drinking (OR = 3.5, 95% CI = 1.6–7.5) including increased number of drinks per day (p-trend = 0.002), and increased years of binge drinking (p-trend = 0.0006). In fully adjusted models that included smoking and other confounders, ORs for binge drinking in men were somewhat higher than in age-adjusted models. Results from our detailed analyses provide support for heavy alcohol consumption (including binge drinking) as a risk factor for PCA in men.
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影响因子：
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