Identification of immune landscape signatures associated with clinical and prognostic features of hepatocellular carcinoma.
Identification of immune landscape signatures associated with clinical and prognostic features of hepatocellular carcinoma.
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鉴定与肝细胞癌临床和预后特征相关的免疫景观特征
DOI：
10.18632/aging.103977
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发表时间：
2020-10-13
期刊：
影响因子：
--
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Yan H;Chen Y;Wang K;Yu L;Huang X;Li Q;Xie Y;Lin J;He Y;Yi X;Wang Y;Chen L;Ding Y;Li Y
尽管癌症免疫疗法在某些恶性肿瘤中取得了非常成功的效果，但一些癌症受到当前免疫疗法的有限益处。在这里，我们将免疫景观特征与肝细胞癌临床和预后特征相结合，以将其分为不同的亚型。然后系统地分析了亚型的免疫基因组，基质细胞特征和免疫细胞组成。基于6个与基质细胞含量相关的差异基因和17个差异表达的基因建立了两个独立的预后指数。这些指数与肿瘤突变负担，不足的DNA不匹配修复和微卫星不稳定性显着相关。此外，肿瘤浸润淋巴细胞，包括活化的NK细胞，静息记忆CD4 T细胞，嗜酸性粒细胞和活化的肥大细胞与肝细胞癌的存活显着相关。总之，我们全面描述了免疫景观特征，并确定了肝细胞癌的预后免疫相关生物标志物。我们的发现突出了潜在的新型途径，以改善对免疫疗法的反应。
While cancer immunotherapy has been remarkably successful in some malignancies, some cancers derive limited benefit from current immunotherapies. Here, we combined immune landscape signatures with hepatocellular carcinoma clinical and prognostic features to classify them into distinct subtypes. The immunogenomic profiles, stromal cell features and immune cell composition of the subtypes were then systematically analyzed. Two independent prognostic indexes were established based on 6 immune-related genes and 17 differentially expressed genes associated with stromal cell content. These indexes were significantly correlated with tumor mutation burden, deficient DNA mismatch repair and microsatellite instability. In addition, tumor-infiltrating lymphocytes, including activated NK cells, resting memory CD4 T-cells, eosinophils, and activated mast cells were significantly correlated with hepatocellular carcinoma survival. In conclusion, we have comprehensively described the immune landscape signatures and identified prognostic immune-associated biomarkers of hepatocellular carcinoma. Our findings highlight potential novel avenues for improving responses to immunotherapy.
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影响因子：
28.2
作者：
Mouw KW;Goldberg MS;Konstantinopoulos PA;D'Andrea AD
通讯作者：
D'Andrea AD
影响因子：
64.5
作者：
Cancer Genome Atlas Research Network. Electronic address: wheeler@bcm.edu;Cancer Genome Atlas Research Network
通讯作者：
Cancer Genome Atlas Research Network
影响因子：
82.9
作者：
Binnewies M;Roberts EW;Kersten K;Chan V;Fearon DF;Merad M;Coussens LM;Gabrilovich DI;Ostrand-Rosenberg S;Hedrick CC;Vonderheide RH;Pittet MJ;Jain RK;Zou W;Howcroft TK;Woodhouse EC;Weinberg RA;Krummel MF
通讯作者：
Krummel MF
影响因子：
10.9
作者：
Beyrend, Guillaume;van der Gracht, Esme;Ossendorp, Ferry
通讯作者：
Ossendorp, Ferry
影响因子：
168.9
作者：
Fehrenbacher, Louis;Spira, Alexander;Rittmeyer, Achim
通讯作者：
Rittmeyer, Achim