Insight into nanoparticle cellular uptake and intracellular targeting.
Insight into nanoparticle cellular uptake and intracellular targeting.
复制标题
深入了解纳米颗粒细胞摄取和细胞内靶向。
DOI：
10.1016/j.jconrel.2014.06.038
复制
发表时间：
2014-09-28
期刊：
影响因子：
--
通讯作者：
Farokhzad OC
中科院分区：
文献类型：
--
作者：
Yameen B;Choi WI;Vilos C;Swami A;Shi J;Farokhzad OC
生物、材料科学和工程领域的合作努力正在导致纳米医学发展的令人兴奋的进步。由于许多治疗剂的靶点位于亚细胞室，因此调节纳米颗粒与细胞之间的相互作用以通过质膜有效地摄取细胞，以及开发精确输送到亚细胞室的纳米药物仍然是一个艰巨的挑战。细胞内化途径对纳米颗粒的内化后命运和细胞内定位有决定性的影响。该综述重点介绍了与非靶向纳米药物领域最相关的细胞摄取途径，并介绍了受体介导的细胞内化配体靶向纳米粒作为调节细胞摄取纳米粒的策略。配体靶向纳米颗粒一直是纳米药物走向临床的主要推动力。这一策略甚至在有效口服纳米药物方面取得了显着进展，这种药物可以克服肠道上皮细胞屏障。还提供了对亚细胞靶向的最新发展的详细概述，该靶向正在成为下一代细胞器特定纳米药物的平台。综述的每个部分都包括靶向纳米药物领域的前景、潜力和具体期望，以及满足这些期望的战略。
Collaborative efforts from the fields of biology, materials science, and engineering are leading to exciting progress in the development of nanomedicines. Since the targets of many therapeutic agents are localized in subcellular compartments, modulation of nanoparticle-cell interactions for an efficient cellular uptake through the plasma membrane, and the development of nanomedicines for precise delivery to subcellular compartments remain formidable challenges. The cellular internalization routes have a determining effect on the post-internalization fate and intracellular localization of nanoparticles. This review highlights the cellular uptake routes most relevant to the field of non-targeted nanomedicine, and presents an account of ligand targeted nanoparticles for receptor mediated cellular internalization as a strategy for modulating the cellular uptake of nanoparticles. Ligand targeted nanoparticles have been the main impetus behind the progress of nanomedicines towards the clinic. This strategy has even resulted in a remarkable development towards effective oral delivery of nanomedicines that can overcome the intestinal epithelial cellular barrier. A detailed overview of the recent developments towards subcellular targeting that is emerging as a platform for the next generation organelle specific nanomedicines is also provided. Each section of the review includes prospect, potential, and concrete expectations from the field of targeted nanomedicines and strategies to meet those expectations.
登录
查看更多内容
影响因子：
8.4
作者：
Borner, MM;Schöffski, P;Fumoleau, P
通讯作者：
Fumoleau, P
影响因子：
64.5
作者：
Brooks, PC;Stromblad, S;Cheresh, DA
通讯作者：
Cheresh, DA
影响因子：
10.8
作者：
Boddapati, Sarathi V.;D'Souza, Gerard G. M.;Weissig, Volkmar
通讯作者：
Weissig, Volkmar
影响因子：
14
作者：
Acharya, Sarbari;Dilnawaz, Fahima;Sahoo, Sanjeeb K.
通讯作者：
Sahoo, Sanjeeb K.
影响因子：
4.9
作者：
Binauld, Sandra;Stenzel, Martina H.
通讯作者：
Stenzel, Martina H.