Regulation of human leukocyte beta receptors by endogenous catecholamines: relationship of leukocyte beta receptor density to the cardiac sensitivity to isoproterenol.
Regulation of human leukocyte beta receptors by endogenous catecholamines: relationship of leukocyte beta receptor density to the cardiac sensitivity to isoproterenol.
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内源性儿茶酚胺对人白细胞β受体的调节：白细胞β受体密度与心脏对异丙肾上腺素敏感性的关系。
DOI：
10.1172/jci110217
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Wood,AJ
中科院分区：
文献类型：
--
作者：
Fraser,J;Nadeau,J;Robertson,D;Wood,AJ
高水平的β受体激动剂已被证明可下调人体循环白细胞的β受体密度；然而，生理条件下控制受体密度的因素尚未明确。为了确定β受体密度是否在正常情况下被循环儿茶酚胺的生理水平下调，我们研究了受体密度和儿茶酚胺水平之间的关系。尿肾上腺素和去甲肾上腺素与淋巴细胞受体密度呈显著负相关。受体密度与仰卧血浆肾上腺素、去甲肾上腺素、直立血浆肾上腺素和去甲肾上腺素水平之间也存在类似的关系。钠摄入量从10 meq/d增加到400 meq/d，导致淋巴细胞增加52%，多形核受体密度增加48%。受体密度的变化伴随着对异丙肾上腺素敏感性的增加，测量值为每分钟心跳提高25次所需的异丙肾上腺素剂量的下降。淋巴细胞和多形核细胞β受体密度与心脏对异丙肾上腺素的敏感性显著相关。心得安导致淋巴细胞和多形核细胞β受体密度的增加，这与受试者的预处理儿茶酚胺水平相关。因此，这些发现表明，人体中儿茶酚胺的生理水平通常会下调β受体，而心得安对这种下调的阻断会使受体密度增加。
High levels of beta receptor agonist have previously been shown to down-regulate beta receptor density on circulating leukocytes in man; however, the factors controlling receptor density under physiological conditions have not previously been defined. To determine whether beta receptor density is normally down-regulated by circulating, physiological levels of catecholamines we have examined the relationship between receptor density and catecholamine levels. Urinary epinephrine and norepinephrine were significantly reciprocally correlated to lymphocyte receptor density. A similar relationship existed between beta receptor density and supine plasma epinephrine, norepinephrine, upright epinephrine, and norepinephrine levels. Change in sodium intake from 10 to 400 meq/d caused a 52% increase in lymphocyte and a 48% increase in polymorphonuclear beta receptor density. The changes in receptor density were accompanied by an increase in the sensitivity to isoproterenol measured as a fall in the dose of isoproterenol required to raise the heart rate by 25 beats per minute. Beta receptor density on both lymphocyte and polymorphonuclear cells was significantly correlated to the cardiac sensitivity to isoproterenol. Propranolol administration resulted in an increase in the density of beta receptors on lymphocyte and polymorphonuclear cells that correlated with the subject's pretreatment catecholamine levels.These findings, therefore, suggest that physiological levels of catecholamines normally down-regulate beta receptors in man and that blockade of this down-regulation by propranolol allows receptor density to increase.
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儿茶酚胺诱导的腺苷酸环化酶不敏感与β-肾上腺素能受体结合位点的丧失相关。
DOI：
10.1073/pnas.72.5.1945
发表时间：
1975
影响因子：
11.1
作者：
C. Mukherjee;M. Caron;R. Lefkowitz
通讯作者：
R. Lefkowitz
(-)-[3H]-二氢阿普洛尔与人多形核细胞颗粒的高亲和力 β2-肾上腺素受体结合的表征。
DOI：
10.5555/uri:pii:0022214378901130
发表时间：
1978
期刊：
The Journal of laboratory and clinical medicine
影响因子：
--
作者：
S. Galant;S. Galant;S. Underwood;S. Underwood;L. Duriseti;L. Duriseti;P. Insel;P. Insel
通讯作者：
P. Insel
通过 [3H]二氢麦角隐亭结合鉴定人血小板中的 α-肾上腺素能受体
DOI：
--
发表时间：
1978
期刊：
影响因子：
--
作者：
Newman Kd;L. Williams;Bishopric Nh;R. Lefkowitz
通讯作者：
R. Lefkowitz
影响因子：
8.3
作者：
NICHOLLS, MG;KIOWSKI, W;GREENHOUSE, J
通讯作者：
GREENHOUSE, J
影响因子：
158.5
作者：
GALANT, SP;DURISETI, L;INSEL, PA
通讯作者：
INSEL, PA