Subclinical myocardial disease by cardiac magnetic resonance imaging and spectroscopy in healthy HIV/Hepatitis C virus-coinfected persons.
Subclinical myocardial disease by cardiac magnetic resonance imaging and spectroscopy in healthy HIV/Hepatitis C virus-coinfected persons.
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DOI：
10.1177/0300060517708919
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发表时间：
2017-12
期刊：
影响因子：
--
通讯作者：
Currier JS
中科院分区：
文献类型：
--
作者：
Chew KW;Liu CY;Ambale-Venkatesh B;Liao D;Horwich TB;Lima JAC;Bluemke DA;Paul Finn J;Butt AA;Currier JS
丙型肝炎病毒（HCV）感染对人类免疫缺陷病毒（HIV）合并感染者心力衰竭风险的影响尚不清楚。其目的是表征心脏功能和形态学在艾滋病毒治疗的合并感染者。在一项横断面研究中，HIV感染患者接受抗逆转录病毒治疗，病毒学抑制，没有已知的心血管疾病或糖尿病，接受心脏磁共振成像和光谱检查，以测量心脏功能，心肌纤维化和脂肪变性。该研究包括18名男性患者，中位年龄为44岁。其中，10人未经治疗的HCV合并感染，8人HIV单一感染。队列中整体收缩和舒张功能正常，心肌脂肪含量中位数为0.48%（四分位数范围0.35-1.54）。左心室（LV）质量指数和LV质量/体积比显着更大的HIV/HCV合并感染组相比，HIV单感染组。在HIV单一感染组，有更多的心肌纤维化细胞外容积分数测量。HIV/HCV合并感染者与HIV单一感染者的心脏结构和形态存在差异。需要更大规模的研究来检查HIV和HCV是否独立地导致心力衰竭的机制。
The contribution of hepatitis C virus (HCV) infection to the risk of heart failure in human immunodeficiency virus (HIV)-coinfected persons is unknown. The objective was to characterize cardiac function and morphology in HIV-treated coinfected persons. In a cross-sectional study, HIV-infected patients virologically suppressed on antiretroviral therapy without known cardiovascular disease or diabetes mellitus underwent cardiac magnetic resonance imaging and spectroscopy for measures of cardiac function, myocardial fibrosis, and steatosis. The study included 18 male patients with a median age of 44 years. Of these, 10 had untreated HCV coinfection and eight had HIV monoinfection. Global systolic and diastolic function in the cohort were normal, and median myocardial fat content was 0.48% (interquartile range 0.35–1.54). Left ventricular (LV) mass index and LV mass/volume ratio were significantly greater in the HIV/HCV-coinfected group compared with the HIV-monoinfected group. In the HIV-monoinfected group, there was more myocardial fibrosis as measured by extracellular volume fraction. There were differences between HIV/HCV-coinfected and HIV-monoinfected patients in cardiac structure and morphology. Larger studies are needed to examine whether HIV and HCV independently contribute to mechanisms of heart failure.
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DOI：
10.1186/s12968-016-0308-4
发表时间：
2016-11-30
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
Haaf P;Garg P;Messroghli DR;Broadbent DA;Greenwood JP;Plein S
通讯作者：
Plein S
DOI：
10.1086/599371
发表时间：
2009-07-15
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Butt AA;Xiaoqiang W;Budoff M;Leaf D;Kuller LH;Justice AC
通讯作者：
Justice AC
影响因子：
39.2
作者：
Levey, Andrew S.;Coresh, Josef;Van Lente, Frederick
通讯作者：
Van Lente, Frederick
影响因子：
9.7
作者：
Hsue, Priscilla Y.;Hunt, Peter W.;Bolger, Ann F.
通讯作者：
Bolger, Ann F.
影响因子：
1.5
作者：
Isasti, Guillermo;Perez, Isabel;Santos, Jesus
通讯作者：
Santos, Jesus