Lineage BA.2 dominated the Omicron SARS-CoV-2 epidemic wave in the Philippines.
Lineage BA.2 dominated the Omicron SARS-CoV-2 epidemic wave in the Philippines.
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作者：
欧米克隆严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）变体于2021年11月在南非被发现后，引发了一波巨大的全球流行浪潮。BA.1 Omicron谱系在2021年12月至2022年1月期间占主导地位，是世界各国大多数SARS-CoV-2暴发的原因，而包括BA.2在内的其他Omicron谱系在全球分离株中占少数。在这里，我们通过分析基因组数据来描述菲律宾的欧米克隆波。我们的研究结果确定了在2022年1月病例激增之前，2021年12月菲律宾存在BA.1和BA.2谱系。我们推断，只有BA.2谱系在该国持续传播，估计在2021年11月18日左右出现（95%最高后验密度：11月6日至28日），而尽管多次引入，BA.1传播仍然有限。这些结果表明，菲律宾是最早受BA.2影响的地区之一，并重申了全基因组测序对监测疫情的重要性。
The Omicron severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant led to a dramatic global epidemic wave following detection in South Africa in November 2021. The BA.1 Omicron lineage was dominant and responsible for most SARS-CoV-2 outbreaks in countries around the world during December 2021–January 2022, while other Omicron lineages, including BA.2, accounted for the minority of global isolates. Here, we describe the Omicron wave in the Philippines by analysing genomic data. Our results identify the presence of both BA.1 and BA.2 lineages in the Philippines in December 2021, before cases surged in January 2022. We infer that only the BA.2 lineage underwent sustained transmission in the country, with an estimated emergence around 18 November 2021 (95 per cent highest posterior density: 6–28 November), while despite multiple introductions, BA.1 transmission remained limited. These results suggest that the Philippines was one of the earliest areas affected by BA.2 and reiterate the importance of whole genome sequencing for monitoring outbreaks.
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影响因子：
6.6
作者：
Yu, Guangchuang;Smith, David K.;Lam, Tommy Tsan-Yuk
通讯作者：
Lam, Tommy Tsan-Yuk
DOI：
10.1126/science.abj9932
发表时间：
2021-11-19
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Dhar MS;Marwal R;Vs R;Ponnusamy K;Jolly B;Bhoyar RC;Sardana V;Naushin S;Rophina M;Mellan TA;Mishra S;Whittaker C;Fatihi S;Datta M;Singh P;Sharma U;Ujjainiya R;Bhatheja N;Divakar MK;Singh MK;Imran M;Senthivel V;Maurya R;Jha N;Mehta P;A V;Sharma P;Vr A;Chaudhary U;Soni N;Thukral L;Flaxman S;Bhatt S;Pandey R;Dash D;Faruq M;Lall H;Gogia H;Madan P;Kulkarni S;Chauhan H;Sengupta S;Kabra S;Indian SARS-CoV-2 Genomics Consortium (INSACOG)‡;Gupta RK;Singh SK;Agrawal A;Rakshit P;Nandicoori V;Tallapaka KB;Sowpati DT;Thangaraj K;Bashyam MD;Dalal A;Sivasubbu S;Scaria V;Parida A;Raghav SK;Prasad P;Sarin A;Mayor S;Ramakrishnan U;Palakodeti D;Seshasayee ASN;Bhat M;Shouche Y;Pillai A;Dikid T;Das S;Maitra A;Chinnaswamy S;Biswas NK;Desai AS;Pattabiraman C;Manjunatha MV;Mani RS;Arunachal Udupi G;Abraham P;Atul PV;Cherian SS
通讯作者：
Cherian SS
影响因子：
6.5
作者：
Rambaut, Andrew;Drummond, Alexei J.;Suchard, Marc A.
通讯作者：
Suchard, Marc A.
影响因子：
64.8
作者：
Viana R;Moyo S;Amoako DG;Tegally H;Scheepers C;Althaus CL;Anyaneji UJ;Bester PA;Boni MF;Chand M;Choga WT;Colquhoun R;Davids M;Deforche K;Doolabh D;du Plessis L;Engelbrecht S;Everatt J;Giandhari J;Giovanetti M;Hardie D;Hill V;Hsiao NY;Iranzadeh A;Ismail A;Joseph C;Joseph R;Koopile L;Kosakovsky Pond SL;Kraemer MUG;Kuate-Lere L;Laguda-Akingba O;Lesetedi-Mafoko O;Lessells RJ;Lockman S;Lucaci AG;Maharaj A;Mahlangu B;Maponga T;Mahlakwane K;Makatini Z;Marais G;Maruapula D;Masupu K;Matshaba M;Mayaphi S;Mbhele N;Mbulawa MB;Mendes A;Mlisana K;Mnguni A;Mohale T;Moir M;Moruisi K;Mosepele M;Motsatsi G;Motswaledi MS;Mphoyakgosi T;Msomi N;Mwangi PN;Naidoo Y;Ntuli N;Nyaga M;Olubayo L;Pillay S;Radibe B;Ramphal Y;Ramphal U;San JE;Scott L;Shapiro R;Singh L;Smith-Lawrence P;Stevens W;Strydom A;Subramoney K;Tebeila N;Tshiabuila D;Tsui J;van Wyk S;Weaver S;Wibmer CK;Wilkinson E;Wolter N;Zarebski AE;Zuze B;Goedhals D;Preiser W;Treurnicht F;Venter M;Williamson C;Pybus OG;Bhiman J;Glass A;Martin DP;Rambaut A;Gaseitsiwe S;von Gottberg A;de Oliveira T
通讯作者：
de Oliveira T
影响因子：
64.8
作者：
Liu, Lihong;Iketani, Sho;Ho, David D.
通讯作者：
Ho, David D.