PDFR and CRY signaling converge in a subset of clock neurons to modulate the amplitude and phase of circadian behavior in Drosophila.
PDFR and CRY signaling converge in a subset of clock neurons to modulate the amplitude and phase of circadian behavior in Drosophila.
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DOI：
10.1371/journal.pone.0018974
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发表时间：
2011-04-29
期刊：
影响因子：
3.7
通讯作者：
Taghert PH
中科院分区：
文献类型：
--
作者：
Im SH;Li W;Taghert PH
为了同步它们的分子节律，昼夜节律起搏神经元必须输入外部和内部定时线索，因此，感觉信息和内部时钟状态之间的信号整合是正常昼夜生理的基础。我们证明了特定的收敛时钟衍生的神经肽信号与大脑深部感光器。我们报告说，神经肽PDF受体和昼夜光感受器CRYPTOCROME（CRY）是精确的共表达在一个子集的起搏器，这些途径一起提供了一个必要的驱动器昼夜控制日常运动节奏。这些会聚信号通路影响节律产生的相位，但也影响其振幅。在这两个途径的情况下，PER节律大大减少，只有那些特定的起搏器，接受会聚输入和PER水平保持在一整天的核高。这表明心脏起搏器出现了大规模失调。行为节律同样被打乱：在光暗条件下，它们是异常的，而在持续的黑暗条件下，它们丢失了。我们推测，环境和时钟衍生信号的收敛可能会产生光的同步检测，对它的协同响应，从而更准确，更有效的重置属性。
To synchronize their molecular rhythms, circadian pacemaker neurons must input both external and internal timing cues and, therefore, signal integration between sensory information and internal clock status is fundamental to normal circadian physiology. We demonstrate the specific convergence of clock-derived neuropeptide signaling with that of a deep brain photoreceptor. We report that the neuropeptide PDF receptor and the circadian photoreceptor CRYPTOCROME (CRY) are precisely co-expressed in a subset of pacemakers, and that these pathways together provide a requisite drive for circadian control of daily locomotor rhythms. These convergent signaling pathways influence the phase of rhythm generation, but also its amplitude. In the absence of both pathways, PER rhythms were greatly reduced in only those specific pacemakers that receive convergent inputs and PER levels remained high in the nucleus throughout the day. This suggested a large-scale dis-regulation of the pacemaking machinery. Behavioral rhythms were likewise disrupted: in light∶dark conditions they were aberrant, and under constant dark conditions, they were lost. We speculate that the convergence of environmental and clock-derived signals may produce a coincident detection of light, synergistic responses to it, and thus more accurate and more efficient re-setting properties.
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影响因子：
64.8
作者：
Grima, B;Chèlot, E;Rouyer, F
通讯作者：
Rouyer, F
DOI：
10.1002/cne.22311
发表时间：
2010-06-01
期刊：
The Journal of comparative neurology
影响因子：
--
作者：
Im SH;Taghert PH
通讯作者：
Taghert PH
影响因子：
9.8
作者：
Peng Y;Stoleru D;Levine JD;Hall JC;Rosbash M
通讯作者：
Rosbash M
影响因子：
2.5
作者：
Johard, Helena A. D.;Yoishii, Taishi;Nassel, Dick R.
通讯作者：
Nassel, Dick R.
影响因子：
64.8
作者：
Stoleru, D;Peng, Y;Rosbash, M
通讯作者：
Rosbash, M