Cardiorespiratory fitness, hippocampal volume, and frequency of forgetting in older adults.
Cardiorespiratory fitness, hippocampal volume, and frequency of forgetting in older adults.
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心肺健康，海马体积和老年人遗忘的频率。
DOI：
10.1037/a0022733
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发表时间：
2011-09
期刊：
影响因子：
2.4
通讯作者：
Kramer, Arthur F.
中科院分区：
文献类型：
--
作者：
Szabo, Amanda N.;McAuley, Edward;Erickson, Kirk I.;Voss, Michelle;Prakash, Ruchika S.;Mailey, Emily L.;Wojcicki, Thomas R.;White, Siobhan M.;Gothe, Neha;Olson, Erin A.;Kramer, Arthur F.
本研究的目的是扩展我们早期的工作，以确定心肺功能与记忆问题的频率通过其对海马和空间工作记忆的影响的程度。我们假设，年龄，性别，教育，身体成分和体力活动的健康，反过来，影响频率的遗忘间接通过海马体积和空间工作记忆的直接决定因素。我们对158名老年人（M年龄= 66.49）的海马体积、空间工作记忆、遗忘频率、BMI、体力活动、人口统计学特征和心肺功能进行了评估。在协方差建模框架内的路径分析被用来检查这些结构之间的关系。性别、年龄、体重指数和教育程度都是心肺适能的重要决定因素。通过海马体积和空间工作记忆的准确性和速度来检验适应性对遗忘频率的影响的假设路径模型都与数据拟合良好。我们的研究结果表明，健康水平较高的老年人表现出更大的海马体积保留，这反过来又与更准确，更快的空间记忆和更少的遗忘事件有关。考虑到老年人报告记忆问题的比例，有必要确定身体活动干预带来的健康改善是否会导致随后的记忆问题减弱或记忆改善。
The purpose of this study was to extend our earlier work to determine the extent to which cardiorespiratory fitness is associated with the frequency of memory problems via its effects on the hippocampus and spatial working memory. We hypothesized that age, sex, education, body composition, and physical activity were direct determinants of fitness which, in turn, influenced frequency of forgetting indirectly through hippocampal volume and spatial working memory. We conducted assessments of hippocampal volume, spatial working memory, frequency of forgetting, BMI, physical activity, demographic characteristics, and cardiorespiratory fitness in 158 older adults (M age = 66.49). Path analyses within a covariance modeling framework were used to examine relationships among these constructs. Sex, age, BMI, and education were all significant determinants of cardiorespiratory fitness. The hypothesized path models testing the effects of fitness on frequency of forgetting through hippocampal volume and accuracy and speed of spatial working memory all fit the data well. Our findings suggest that older adults with higher levels of fitness show greater preservation of hippocampal volume which, in turn, is associated with more accurate and faster spatial memory and fewer episodes of forgetting. Given the proportion of older adults reporting memory problems, it is necessary to determine whether improvements in fitness brought about by physical activity interventions can result in subsequent attenuation of memory problems or potentially improvements in memory.
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DOI：
10.1080/10705519909540118
发表时间：
1999-01-01
影响因子：
6
作者：
Hu, Li-tze;Bentler, Peter M.
通讯作者：
Bentler, Peter M.
影响因子：
3.5
作者：
Erickson, Kirk I.;Prakash, Ruchika S.;Voss, Michelle W.;Chaddock, Laura;Hu, Liang;Morris, Katherine S.;White, Siobhan M.;Wojcicki, Thomas R.;McAuley, Edward;Kramer, Arthur F.
通讯作者：
Kramer, Arthur F.
影响因子：
120.7
作者：
Carnethon, MR;Gulati, M;Greenland, P
通讯作者：
Greenland, P
DOI：
10.1111/j.1532-5415.1999.tb03848.x
发表时间：
1999-07-01
影响因子：
6.3
作者：
Hoyl, MT;Alessi, CA;Rubenstein, LZ
通讯作者：
Rubenstein, LZ
影响因子：
120.7
作者：
Blair, SN;Kampert, JB;Gibbons, LW
通讯作者：
Gibbons, LW