Aerobic fitness is associated with hippocampal volume in elderly humans.
Aerobic fitness is associated with hippocampal volume in elderly humans.
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DOI：
10.1002/hipo.20547
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发表时间：
2009-10
期刊：
影响因子：
3.5
通讯作者：
Kramer, Arthur F.
中科院分区：
文献类型：
--
作者：
Erickson, Kirk I.;Prakash, Ruchika S.;Voss, Michelle W.;Chaddock, Laura;Hu, Liang;Morris, Katherine S.;White, Siobhan M.;Wojcicki, Thomas R.;McAuley, Edward;Kramer, Arthur F.
海马体的退化发生在患有和不患有痴呆症的老年人中，但海马体退化的程度和速度存在个体差异。确定影响海马退化程度和速度的个体差异的因素可能有助于促进生活方式的改变，从而防止这种退化的发生。有氧健身和运动可以有效预防老年人的皮质衰退和认知障碍，流行病学研究表明，体育活动可以降低患痴呆症的风险。然而，老年人有氧适能与海马体积之间的关系尚不清楚。在这项研究中，我们调查了有氧健身水平较高的个体是否比健身水平较低的个体表现出更大的海马体体积和更好的空间记忆表现。此外，在探索性分析中，我们评估了海马体体积是否介导了健身和空间记忆之间的关系。通过对165名非痴呆老年人的磁共振图像进行兴趣区分析，我们发现了一种三重关联：在控制了年龄、性别和受教育年数后，较高的健康水平与较大的左右海马体相关，而较大的海马体和较高的健康水平与较好的空间记忆表现相关。此外，我们证明了海马体体积部分介导了更高的健康水平和增强的空间记忆之间的关系。我们的研究结果清楚地表明，在老年人中，更高水平的有氧健身与海马体积增加有关，这意味着更好的记忆功能。
Deterioration of the hippocampus occurs in elderly individuals with and without dementia, yet individual variation exists in the degree and rate of hippocampal decay. Determining the factors that influence individual variation in the magnitude and rate of hippocampal decay may help promote lifestyle changes that prevent such deterioration from taking place. Aerobic fitness and exercise are effective at preventing cortical decay and cognitive impairment in older adults and epidemiological studies suggest that physical activity can reduce the risk for developing dementia. However, the relationship between aerobic fitness and hippocampal volume in elderly humans is unknown. In this study, we investigated whether individuals with higher levels of aerobic fitness displayed greater volume of the hippocampus and better spatial memory performance than individuals with lower fitness levels. Furthermore, in exploratory analyses, we assessed whether hippocampal volume mediated the relationship between fitness and spatial memory. Using a region-of-interest analysis on magnetic resonance images in 165 nondemented older adults, we found a triple association such that higher fitness levels were associated with larger left and right hippocampi after controlling for age, sex, and years of education, and larger hippocampi and higher fitness levels were correlated with better spatial memory performance. Furthermore, we demonstrated that hippocampal volume partially mediated the relationship between higher fitness levels and enhanced spatial memory. Our results clearly indicate that higher levels of aerobic fitness are associated with increased hippocampal volume in older humans, which translates to better memory function.
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