Non-tumoral uptake of (68)Ga-FAPI-04 PET: A retrospective study.
Non-tumoral uptake of (68)Ga-FAPI-04 PET: A retrospective study.
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68Ga-FAPI-04 PET 的非肿瘤摄取：回顾性研究
DOI：
10.3389/fonc.2022.989595
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发表时间：
2022
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
基于成纤维细胞活化蛋白（FAP）特异性抑制剂（FAPI）的FAP靶向放射性药物被认为是FDG的潜在替代药物，用于肿瘤特异性成像。然而，FAP也在正常成人组织中表达。本研究的目的是探索非肿瘤区域高摄取68 Ga-FAPI-04在正电子发射断层扫描（PET）成像中的图像特征，并揭示这些区域的生理机制。本回顾性研究共纳入了137例接受全身68 Ga-FAPI-04 PET/MR（n=46）或PET/CT（n=91）的患者。三位经验丰富的核医学医生根据其他成像方式（CT、MRI、18F-FDG PET或超声）、临床信息或病理结果确定非肿瘤区域。手动绘制感兴趣区域（ROI），并测量最大标准摄取值（SUVmax）。本研究共纳入392个非肿瘤摄取区域。包括子宫（n=38）、颌下腺（n=118）、乳头（n=37）、牙龈（n=65）和食管（n=31）。生理区域中的68 Ga-FAPI-04摄取的发生率与年龄无关，牙龈和食管中的示踪剂摄取在男性患者中更常见（p=0.006，0.009），而乳头中的示踪剂摄取在女性患者中更常见（p < 0.001）。良性病变包括炎性淋巴结（n =10）、肺炎（n=13）、动脉粥样硬化（n=10）、胰腺炎（n=18）、骨质疏松（n=45）和手术瘢痕（n=7）。SUVmax在生理区和良性区之间无显著差异。许多器官表现出对68 Ga-FAPI-04的生理摄取。我们的研究表明，具有高68 Ga-FAPI-04摄取的区域不一定代表恶性肿瘤。熟悉生理和典型的良性68 Ga-FAPI-04摄取区域有助于医生解读图像并做出准确诊断。
Fibroblast activation protein (FAP)-targeting radiopharmaceutical based on the FAP-specific inhibitor (FAPI) is considered as a potential alternative agent to FDG for tumor-specific imaging. However, FAP is also expressed in normal adult tissues. The aim of this study was to explore the image features of non-tumoral regions with high uptake of 68Ga-FAPI-04 in positron emission tomography (PET) imaging and to reveal the physiological mechanisms of these regions. A total of 137 patients who underwent whole-body 68Ga-FAPI-04 PET/MR (n=46) or PET/CT (n=91) were included in this retrospective study. Three experienced nuclear medicine physicians determined the non-tumoral regions according to other imaging modalities (CT, MRI, 18F-FDG PET, or ultrasound), clinical information, or pathological results. The regions of interest (ROIs) were drawn manually, and the maximum standardized uptake value (SUVmax) was measured. A total of 392 non-tumoral uptake regions were included in this study. The included physiological regions were uterus (n=38), submandibular gland (n=118), nipple (n=37), gingiva (n=65), and esophagus (n=31). The incidence of 68Ga-FAPI-04 uptake in physiological regions was independent of age, the tracer uptakes in the gingiva and esophagus were more common in male patients (p=0.006, 0.009), while that in the nipple was more common in female patients (p < 0.001). The included benign regions were inflammatory lymph node (n =10), pneumonia (n=13), atherosclerosis (n=10), pancreatitis (n=18), osteosclerosis (n=45), and surgical scar (n=7). No significant difference was observed in SUVmax between physiological and benign regions. A number of organs exhibit physiological uptakes of 68Ga-FAPI-04. Our study showed that regions with high 68Ga-FAPI-04 uptake did not necessarily represent malignancy. Being familiar with physiological and typical benign 68Ga-FAPI-04 uptake regions can be helpful for physicians to interpret images and to make an accurate diagnosis.
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影响因子：
7.3
作者：
Poplawski, Sarah E.;Lai, Jack H.;Li, Youhua;Jin, Zhiping;Liu, Yuxin;Wu, Wengen;Wu, Yong;Zhou, Yuhong;Sudmeier, James L.;Sanford, David G.;Bachovchin, William W.
通讯作者：
Bachovchin, William W.
影响因子：
8
作者：
Puré E;Blomberg R
通讯作者：
Blomberg R
影响因子：
1.5
作者：
Kou, Ying;Jiang, Xuemei;Cheng, Zhuzhong
通讯作者：
Cheng, Zhuzhong
DOI：
10.2967/jnumed.120.245084
发表时间：
2021-03
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Giesel FL;Adeberg S;Syed M;Lindner T;Jiménez-Franco LD;Mavriopoulou E;Staudinger F;Tonndorf-Martini E;Regnery S;Rieken S;El Shafie R;Röhrich M;Flechsig P;Kluge A;Altmann A;Debus J;Haberkorn U;Kratochwil C
通讯作者：
Kratochwil C
影响因子：
13.5
作者：
Levy, MT;McCaughan, GW;Gorrell, MD
通讯作者：
Gorrell, MD