Cognitive side effects of cancer therapy demonstrate a functional role for adult neurogenesis.

Cognitive side effects of cancer therapy demonstrate a functional role for adult neurogenesis.
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DOI:
10.1016/j.bbr.2011.05.012
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发表时间:
2012-02-14
影响因子:
2.7
通讯作者:
Dietrich, Joerg
Dietrich, Joerg
中科院分区:
心理学3区
文献类型:
--
作者:
Monje, Michelle;Dietrich, Joerg

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癌症治疗经常导致一系列神经认知缺陷,包括学习、记忆、注意力和信息处理速度受损。大脑中动态神经祖细胞群的损伤正在成为重要的病因。放射和化疗引起的对负责成人海马神经发生和维持皮质下白质完整性的神经祖细胞群的损害现在被认为在许多癌症幸存者经历的神经认知障碍中发挥着重要作用。
Cancer therapies frequently result in a spectrum of neurocognitive deficits that include impaired learning, memory, attention and speed of information processing. Damage to dynamic neural progenitor cell populations in the brain are emerging as important etiologic factors. Radiation and chemotherapy-induced damage to neural progenitor populations responsible for adult hippocampal neurogenesis and for maintenance of subcortical white matter integrity are now believed to play major roles in the neurocognitive impairment many cancer survivors experience.
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