Cognitive side effects of cancer therapy demonstrate a functional role for adult neurogenesis.
Cognitive side effects of cancer therapy demonstrate a functional role for adult neurogenesis.
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DOI:
10.1016/j.bbr.2011.05.012
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发表时间:
2012-02-14
影响因子:
2.7
通讯作者:
Dietrich, Joerg
中科院分区:
文献类型:
--
作者:
Monje, Michelle;Dietrich, Joerg
Cancer therapies frequently result in a spectrum of neurocognitive deficits that include impaired learning, memory, attention and speed of information processing. Damage to dynamic neural progenitor cell populations in the brain are emerging as important etiologic factors. Radiation and chemotherapy-induced damage to neural progenitor populations responsible for adult hippocampal neurogenesis and for maintenance of subcortical white matter integrity are now believed to play major roles in the neurocognitive impairment many cancer survivors experience.
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