Clinical PDT dose dosimetry for pleural Photofrin-mediated photodynamic therapy.
Clinical PDT dose dosimetry for pleural Photofrin-mediated photodynamic therapy.
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DOI：
10.1117/1.jbo.29.1.018001
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发表时间：
2024-01
影响因子：
3.5
通讯作者：
中科院分区：
文献类型：
--
作者：
光动力疗法（PDT）是利用光激活光敏剂（PS）的既定癌症治疗。有效的治疗取决于PDT剂量依赖于PS浓度和随时间传递的光通量。我们介绍了一种创新的八通道PDT剂量测定系统，能够同时测量治疗过程中的光通量和PS浓度。我们的目的是开发和评估一个八通道PDT剂量剂量测量系统，同时测量光通量和PS浓度。通过解决由于组织变化引起的不确定性，该系统增强了精确的PDT剂量测定，以改善治疗效果。该研究在PDT之前将八个各向同性探测器战略性地定位在胸膜腔内。这些探测器连接到分叉光纤，将信号分配到光电二极管和光谱仪。校准技术被应用于对抗组织相关的变化并提高测量精度。使用测量的光通量对荧光信号进行归一化，补偿组织特性的变化。在20例患者的胸膜腔中的78个部位进行测量。观察结果显示，PDT期间每个部位的Photofrin浓度变化极小，并伴有显著的患者内和患者间异质性。在20例患者的78个治疗部位中，所有78个部位的平均Photofrin浓度为，中位浓度为。所有78个部位的平均PDT剂量为，中位剂量为。观察到PDT剂量的显著变化，在一名患者的所有部位之间的最大差异为3.1倍，在所有患者之间的最大差异为9.8倍。介绍了八通道PDT剂量测定系统作为一个有价值的实时监测工具，光通量和PS浓度在PDT。它能够减轻组织特性引起的不确定性，提高剂量测定的准确性，从而优化治疗结果，并增强PDT在癌症治疗中的有效性。
Photodynamic therapy (PDT) is an established cancer treatment utilizing light-activated photosensitizers (PS). Effective treatment hinges on the PDT dose-dependent on PS concentration and light fluence-delivered over time. We introduce an innovative eight-channel PDT dose dosimetry system capable of concurrently measuring light fluence and PS concentration during treatment. We aim to develop and evaluate an eight-channel PDT dose dosimetry system for simultaneous measurement of light fluence and PS concentration. By addressing uncertainties due to tissue variations, the system enhances accurate PDT dosimetry for improved treatment outcomes. The study positions eight isotropic detectors strategically within the pleural cavity before PDT. These detectors are linked to bifurcated fibers, distributing signals to both a photodiode and a spectrometer. Calibration techniques are applied to counter tissue-related variations and improve measurement accuracy. The fluorescence signal is normalized using the measured light fluence, compensating for variations in tissue properties. Measurements were taken in 78 sites in the pleural cavities of 20 patients. Observations reveal minimal Photofrin concentration variation during PDT at each site, juxtaposed with significant intra- and inter-patient heterogeneities. Across 78 treated sites in 20 patients, the average Photofrin concentration for all 78 sites is , with a median concentration of . The average PDT dose for all 78 sites is , with a median dose of . A significant variation in PDT doses is observed, with a maximum difference of 3.1 times among all sites within one patient and a maximum difference of 9.8 times across all patients. The introduced eight-channel PDT dose dosimetry system serves as a valuable real-time monitoring tool for light fluence and PS concentration during PDT. Its ability to mitigate uncertainties arising from tissue properties enhances dosimetry accuracy, thus optimizing treatment outcomes and bolstering the effectiveness of PDT in cancer therapy.
用于胸膜光动力治疗期间光剂量测定的红外导航系统。
影响因子：
3.5
作者：
Kim MM;Zhu TC;Ong YH;Finlay JC;Dimofte A;Singhal S;Glatstein E;Cengel KA
通讯作者：
Cengel KA
影响因子：
3.3
作者：
Qiu H;Kim MM;Penjweini R;Finlay JC;Busch TM;Wang T;Guo W;Cengel KA;Simone CB 2nd;Glatstein E;Zhu TC
通讯作者：
Zhu TC